Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.

The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.

We are seeking a highly motivated and experienced scientist specializing in recombinant protein production to join our dynamic research team and accelerate our Cryo-Electron Microscopy and Crystallography workflows. The successful candidate will play a pivotal role in the expression, purification, and characterization of recombinant proteins and complexes for structural studies supporting small molecule and biologics drug discovery. This position requires a deep understanding of protein chemistry for structural and biophysical studies, great wet lab skills, and a team-oriented approach to delivering high-quality samples within project timelines. In addition, the candidate would require experience managing a protein production laboratory and external collaborations/CRO's, and the ability to oversee both scientific and operational aspects of the lab to support a diverse portfolio of projects.

The ideal candidate will have a strong background in protein expression in bacterial, insect and mammalian systems and excellent protein purification skills using standard techniques for cryo-EM and crystallography, as well as for reagent generation for assays.

Key Responsibilities:

• Protein Expression: Transfection of plasmids into mammalian cells to express key viral proteins.
• Protein Purification: Design, optimize, and execute protocols for the purification of recombinant proteins using various chromatography techniques (e.g., affinity, ion exchange, size exclusion).
• Biophysical Characterization: Perform biophysical characterization of purified proteins, including but not limited to, SDS-PAGE, analytical SEC, and Differential Scanning Fluorimetry (DSF).
• Data Analysis & Reporting: Maintain detailed records of experimental designs, data, and results. Analyze and interpret data for presentation to key stakeholders.
• Team Collaboration: Collaborate closely with design team to determine protein constructs with optimal stability and functionality.

Qualifications (Minimal acceptable level of education, work experience, and competence)

• Advanced degree in chemistry, structural biology, biochemistry or related field with relevant experience in biotech or large Pharmaceutical company.
• Proven experience supporting drug discovery programs using structural biology and biochemistry.
• Good communication and interpersonal skills.
• Proven experience working with matrix teams
• Self-driven, creative and entrepreneurial with ability to support multiple programs simultaneously.
• Cryo-EM and Crystallography experience highly is desirable, but not required.
• Develop and implement short and long-term strategies to enhance protein production capabilities.
• Provide guidance on cloning, protein expression, purification, and biochemical and biophysical characterization
• Help troubleshooting recombinant protein expression and purification
• Protein engineering experience is desirable but not required
• May train, mentor, and supervise a team of scientists, technicians, and support staff
• Membrane protein experience is desirable but not required
• Knowledge of protein prediction and computational approaches for protein design
• Stay current on emerging technologies and instrumentation in protein chemistry and biochemistry to introduce innovative approaches to the facility
• Troubleshoot and optimize workflows to improve the efficiency and reproducibility of experimental results.

Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

The Incyte hiring organization processes your personal data to manage your job application in order to enter into an employment relationship with you if you are the successful candidate.

During the process, you may be asked to respond to questions that will screen out your application if you do not meet certain objective criteria required by the job.

You may have the right to access, delete, restrict, edit, move, or object to the use of your personal data. You may also have a right to report concerns to the authority responsible for data privacy in the country where the position is based or where you live or work.

By accessing this link you can learn about the types of personal data we collect, how we use it, whether collection and processing is optional, sources of the personal data we process, how it is shared, where it is stored or transferred to, how long we keep it, and contact information for Incyte, Incyte's data protection officer, and your supervisory authority (if applicable).