Sr Scientist I, Cell and Molecular Biology
- Employer
- AbbVie
- Location
- South San Francisco, California, US
- Salary
- Competitive
- Closing date
- Oct 13, 2024
View more categoriesView less categories
- Sector
- Consultancy/Private Sector
- Field
- Conservation science
- Discipline
- Biology
- Salary Type
- Salary
- Employment Type
- Full time
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Job Description
The Development Sciences Biologics CMC Drug Substance Cell Line Development Group in South San Francisco, CA is seeking a Senior Scientist to join a talented and collaborative team developing CHO cell lines for GMP applications.
In this laboratory position, the candidate will perform hands-on molecular characterization studies in a well-supported and dynamic environment to help advance novel therapies to human clinical studies. The work will encompass molecular, cellular, and bioprocess development studies relating to the generation and characterization of optimized CHO cell lines for production of our pipeline candidates.
Key Responsibilities:
Design, test and optimize DNA vector constructs, vector workflow for protein expression (including monoclonal antibodies and antibody-like molecules) in CHO cells, and occasionally other hosts.
Perform genetic characterization of CHO cell lines/banks using multiple methods (ddPCR, MinION and P2 NGS, TLA, blotting) to confirm identity, quality, stability of transgene DNA and RNA. Manage and analyze all associated data, including NGS data.
Optimize genetic characterization workflows for technological advancement, efficiency and timeline improvement.
Display effective organization, verbal and written communication skills, and adherence to good documentation practices, including real time entry of lab work into electronic lab notebook.
Author detailed technical reports that support regulatory filings at all stages from IND to BLA.
Present updates at team meetings and collaborate closely with others in the cell line development group.
The Development Sciences Biologics CMC Drug Substance Cell Line Development Group in South San Francisco, CA is seeking a Senior Scientist to join a talented and collaborative team developing CHO cell lines for GMP applications.
In this laboratory position, the candidate will perform hands-on molecular characterization studies in a well-supported and dynamic environment to help advance novel therapies to human clinical studies. The work will encompass molecular, cellular, and bioprocess development studies relating to the generation and characterization of optimized CHO cell lines for production of our pipeline candidates.
Key Responsibilities:
Design, test and optimize DNA vector constructs, vector workflow for protein expression (including monoclonal antibodies and antibody-like molecules) in CHO cells, and occasionally other hosts.
Perform genetic characterization of CHO cell lines/banks using multiple methods (ddPCR, MinION and P2 NGS, TLA, blotting) to confirm identity, quality, stability of transgene DNA and RNA. Manage and analyze all associated data, including NGS data.
Optimize genetic characterization workflows for technological advancement, efficiency and timeline improvement.
Display effective organization, verbal and written communication skills, and adherence to good documentation practices, including real time entry of lab work into electronic lab notebook.
Author detailed technical reports that support regulatory filings at all stages from IND to BLA.
Present updates at team meetings and collaborate closely with others in the cell line development group.
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