Research Scientist, Biology

Job Description Summary

Location: Cambridge, MA

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About the role:

The Novartis Oncology Disease Area is seeking a highly motivated, creative, and collaborative scientist to join the Biological Chemistry (BC) group in a hands-on role to discover the next generation of innovative cancer treatments. We are an early-stage drug discovery team focused on understanding and exploiting the molecular mechanisms of novel cancer targets for the discovery, characterization, and optimization of small molecule therapeutics.

Job Description

Key Responsibilities:

Design, develop, and troubleshoot biochemical/biophysical assays using various detection technologies to identify and characterize cancer targets and small molecule modulators.

Measure binding affinity, binding kinetics, and understand the mode of binding of ligands to proteins of interest.

Assess and implement emerging cutting-edge technologies and novel assay approaches to advance drug discovery programs.

Contribute to medicinal chemistry drug discovery efforts to evaluate compound SAR and mode of action characterization.

Communicate, collaborate, and challenge assumptions to push scientific boundaries with a diverse team of cross-functional scientists.

Essential Requirements:

This position will be located at the Cambridge, MA site and will not have the ability to be located remotely. This position will not require travel as defined by the business (domestic and/or international).

Minimum of a bachelor's degree in Biochemistry, Biophysics, Enzymology, or a related field with 1+ years of relevant laboratory research experience through employment, internships, or co-operative study programs. Or minimum of a master's degree with 0-1 years of relevant laboratory research experience through employment, internships, or co-operative study programs.

Solid understanding of protein function and enzyme mechanism; experience with biochemical and/or biophysical assay development for protein target and small molecule inhibitor characterizations as well as protein-ligand binding interactions.

Strong technical ability at the bench, an eagerness to learn new things, and the willingness to tackle challenging scientific questions.

Experience collaborating with multidisciplinary project teams.

Experience with one or more of the following: fluorescence-based assay techniques (e.g., HTRF, FP, or quench assays) and label-free technologies (e.g., SPR, ITC, DSF, or mass spectrometry).

Proven ability to analyze, interpret and present data in a clear and concise manner.

Excellent team player, with strong communication and inter-personal skills.

Desirable Requirements:

Hands-on experience with automation to enable medium to high throughput assays.

Salary Range:

$66,000.00 - $99,000.00

Commitment to Diversity and Inclusion:

Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

EEO Statement:

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion, or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

Accessibility and Reasonable Accommodations:

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to tas.nacomms@novartis.com or call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

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