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Senior Scientific Lead, ADC, Large Molecule Biology

Eli Lilly and Company
New York City, New York, US
Closing date
Jul 16, 2024

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Academic / Research
Conservation science
Salary Type
Employment Type
Full time
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.


At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.


Position Summary:

You will collaborate with a dynamic group of scientists (internal team as well as external CROs) conducting various research projects to identify large molecule/biologics which can effectively treat various forms of cancer. This is a senior role with significant hands-on responsibilities where you will lead from the bench. You will design and perform experiments that determine the efficacy of pipeline agents through a variety of techniques such as in vitro and ex vivo assays, target validation, and functional screening. Collaboration across functional areas within Oncology is required including senior leadership. You will be a key member of the Biologics organization, where you will be responsible for maintaining the scientific quality and efficiency of your organization, as well as assist and contribute to the strategic direction of large molecule discovery.

*Roles and Responsibilities of the Position:
  • Design and oversee the execution of key mechanistic and discovery biology experiments with ADCs or CD3 T-cell biologics
  • Maintain focus on project deliverables and prioritize experiments and efforts accordingly
  • Oversee/perform assays to identify the drug candidate and evaluate the candidate for clinical testing
  • Liaise with CROs and vendors to outsource activities, provide input to management team on vendor selection
  • Provide scientific expertise when determining organizations to strategically partner with
  • Interrogate experimental conduct of third parties/vendors
  • Participate in target identification in collaboration with leadership
  • Indirectly oversee work of third parties/vendors (e.g., CROs)
  • Manage resource allocation effectively
  • Build roadmaps to execute on specific targets, and overall strategic projects

*Required Qualifications:
  • PhD in cellular biology, immunology, or allied disciplines with minimum 3+ years' industry experience OR BS/MS with 10+ years of direct pharmaceutical/biotechnology experience.
  • Experience in leading a project (i.e., to IND, FHD and/or out licensing) highly preferred

Additional Preferences:
  • Experience writing reports and supporting documentation for regulatory filings preferred
  • Hands-on experience with in-vitro assay development for large molecules including ADCs and other modalities
  • Strong attention to detail and highly goal oriented with demonstrated critical thinking capabilities
  • Ability to trouble shoot effectively and think outside of the box
  • Ability to collaborate with translational biology functions (PK/PD, toxicology, Ab discovery)
  • Proven success leading, managing, and coaching others (either directly or indirectly)
  • Demonstrated ability and track record in managing work overseen by third parties/vendors/strategic partners
  • Demonstrated experience in working collaboratively across various scientific disciplines to meet end goals of business
  • Demonstrated excellence in making key strategic decisions in support of broader business goals
  • Excellent written and verbal communication skills

Physical Demands/ Travel:

The physical demands of this job are consistent with laboratory/bench setting

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position's work environment is in a lab.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions

Lilly currently anticipates that the base salary for this position could range from between $143,250 to $210,100 and will depend, in part, on the successful candidate's qualifications for the role, including education and experience. Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Of course, the compensation described above is subject to change and could be higher or lower than the range described above. Further, Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively "Lilly") are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women's Network, Working and Living with Disabilities. Learn more about all of our groups.


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