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Associate Director, ADC Biology & Development, Oncology R&D

South Waltham, Massachusetts, US
Closing date
Jun 23, 2024

View more

Academic / Research
Genetics, Biology
Salary Type
Employment Type
Full time
Do you feel passionate about the possibilities of great science changing lives of cancer patients? Do you have a background within oncology research or target identification and have interest in working with antibody drug conjugates (ADCs) and an exciting portfolio? If so, this may be the role for you.

We currently have an exciting opportunity for a highly motivated Associate Director to lead a team of scientists exploring ADC target discovery and biology.

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. Within AstraZeneca Oncology R&D, we are committed to advancing the science to deliver life-changing medicines to patients most in need. With a combination-focused pipeline that exploits the power of six scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy and Epigenetics) to help address unmet clinical needs in a host of cancers, we are motivated by a dedication to the scientific discovery and collaboration that will one day help eliminate cancer as a cause of death.

What you'll do

We are seeking an AssociateDirector in Tumor Targeted Delivery (TTD) to develop a comprehensive strategy to discover new targets for ADCs, understand the role of targets in cancer biology and support novel ADC platform and project development. Working in partnership with the TTD team across the globe, lead the implementation of novel target biology and discovery efforts.

  • Lead a team focused on cancer biology-based target discovery for ADCs
  • Collaborate with internal teams to prioritize targets, develop target identification and validation strategies
  • Support project teams with early validation work and exploration of target biology
  • Interface with Tumor Councils and strategy teams to provide scientific leadership and gain feedback for ADC development
  • Lead internal and external research collaborations supporting target discovery and biology

Essential for the role
  • PhD and/or MD with experience in drug development
  • A minimum of 5 years of relevant experience
  • In-depth knowledge of ADCs and oncology disease area biology (solid tumors); experience with both ADC and immune conjugates is desirable
  • Ability to drive, manage, execute and deliver results for complex multi-functional projects
  • Highly developed problem solving and risk management skills, and attention to detail
  • Highly developed collaborative working skills
  • Ability to act as an external ambassador and to influence external organisations to enhance the image and reputation of AstraZeneca
  • Established ability to lead a team, setting goals and objectives, empower and develop team members and influence recruitment of high performing staff

Desirable for the role
  • Experience in ADCs with different types of antibody formats, linker-payloads and conjugation chemistries

Our Waltham, Massachusetts facility develops life changing small-molecule research in North America, with innovative laboratories at the Gatehouse Park Bio Hub, just west of the city center. Our BioHub facility, is a bold new R&D initiative, which fosters life science discoveries and the exchange of ideas. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. With a shuttle bus to and from Alewife station, the location provides you the ability to work in the heart of one of the world's most vibrant research centers.

Our Waltham site offers a variety of amenities help keep our employees happy and engaged. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams and the greater research community.

"When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world."

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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