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Scientist II, Computational Biology

Life Edit Therapeutics
Durham, North Carolina, US
Closing date
May 25, 2024

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Academic / Research
Informatics / GIS
Salary Type
Employment Type
Full time
The Role:

The Bioinformatics and Computational Biology group at Life Edit supports and interacts with all areas of the company. We are looking for a motivated scientist with a background in genomics and sequencing technology to help design and analyze large datasets related to gene editing experiments. We are seeking curious, enthusiastic, competent, and self-motivated individuals with strong emotional intelligence to work in our company. A willingness to embrace our cultural values will be critical for success in this role. This is an exciting opportunity to help build a successful therapeutics company from an early stage. Life Edit Therapeutics Inc. is a dynamic, high-growth, and intellectually challenging workplace with projects that span discovery and development of novel gene editing tools to therapeutic applications for clinical indications.

Here's What You'll Do:
  • Develop and optimize analysis workflows to analyze NGS data, including both whole genome sequencing (WGS/WES), targeted sequencing, and bulk/single cell RNA Seq
  • Develop novel Bioinformatics methods to answer platform and biological questions, and demonstrate validity of methods through prototypes and benchmarking using appropriate controls
  • Work with other computational biologists and computational engineers to deliver and optimize production-level pipelines
  • Proper documentation of code, workflows, and analyses including study reports for nonclinical and clinical studies and regulatory filings
  • Communicate to a broad audience with a range of technical, analytical, and biological expertise and present results on a regular basis at various group meetings

  • A PhD and 3+ years post-PhD experience in bioinformatics, computational biology, and data science.
  • Demonstrated experience in the field of computational biology, CRISPR off target genomics, cancer genomics, and/or single-cell genomics.
  • Extensive expertise in analyzing, interpreting, and visualizing human genomics datasets generated by high-throughput sequencing technologies including short- (Illumina) and long-read- (e.g. PacBio and Oxford Nanopore) sequencing.
  • Extensive experience performing statistical analyses of large genomic datasets and validation of genomic pipelines.
  • Expert-level proficiency in relevant programming languages such as R and Python
  • Proficiency in tools for ensuring reproducibility of pipelines, such as workflow management systems (e.g., nextflow or snakemake), and version control (e.g., git).
  • Demonstrated ability to troubleshoot independently.
  • Experience with CRISPR editing, base editing, or prime editing is preferred.
  • Familiarity with AWS, SQL, and working in a Unix environment.
  • Exceptional oral and written communication skills
  • Benchling or Tableau experience is a plus.

Why join Life Edit and the ElevateBio ecosystem?

Life Edit Therapeutics is an integrated subsidiary of ElevateBio, a technology-driven cell and gene therapy company that is accelerating access to the cutting-edge technologies and expertise that can change the future of medicine. Our integrated model combines multiple R&D technology platforms - including Life Edit gene editing - and cGMP manufacturing to power the discovery and development of advanced therapeutics. Our ecosystem is designed to enhance speed, delivery, and probability of success to change patient lives.

Life Edit is an integral part of ElevateBio's ecosystem of platform technologies and is pioneering focused next-generation gene editing technologies and therapeutics. Located in Durham, NC, members of Life Edit work closely with the ElevateBio Research and Development and BaseCamp manufacturing teams in Waltham, MA. Life Edit is advancing therapeutic programs in collaboration with industry partners while building its own internal pipeline of gene editing therapies. We are looking for a unique individual who can continue to lead the cultural development of Life Edit and build on its momentum as an integral part of the ElevateBio ecosystem.

Our Mission:
To power the creation of life-transforming cell and gene therapies, at a speed the world deserves.

Our Vision:
We seek to be the world's most indispensable cell and gene therapy technology company, redefining how companies operate, how products are created and how disease is treated.

ElevateBio is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. ElevateBio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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