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Senior Scientist- Molecular Biology

San Carlos, California, US
Closing date
May 16, 2024

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Academic / Research
Informatics / GIS
Salary Type
Employment Type
Full time
Job DescriptionJob Description
Elegen is blazing a path towards a biology-based economy with a highly innovative approach to DNA synthesis that delivers an industry leading length of 7kb in 7 business days with a 99.999% per base accuracy. Our multidisciplinary team of best-in-class biologists, chemists, hardware, and software engineers apply cutting-edge technologies and methods to solve critical bottlenecks in synthetic biology workflows to help our customers in pharma, biotech, agbio, and biomanufacturing streamline their work and realize the full potential of programmable biology.

This is an opportunity to join a rapidly growing company at an early stage and to have an impact on the development of its products, markets, processes, people, and culture.

We are seeking an intensely passionate and creative molecular biologist to develop our synthetic DNA production platform to reduce cost and support key verticals in mRNA vaccine manufacturing, cell and gene therapy, and synthetic biology. This is a rare and exciting opportunity for a scientist looking to push the boundaries of DNA synthesis at a uniquely innovative, rapidly moving, high impact start-up. In addition to developing novel DNA synthesis and plasmid assembly methods, you will help us establish a strong culture of mutual respect, integrity, and collaboration while working alongside some of Silicon Valley's best scientists and engineers.

Essential Responsibilities:
  • Drive the development of high throughput gene synthesis and modification protocols from early concept through validation and commercialization stages.
  • Design and execute hypothesis-driven, systematic experimental plans and interpret data using statistical analysis
  • Develop analytical methodologies to aid product development and work closely with bioinformatics to develop sequencing-based QC techniques.
  • Support the transfer of molecular biology protocols to production.
  • Develop protocols into reproducible standard operating procedures suitable for commercial release and support product documentation.

Essential Qualifications and Experience:
  • PhD in molecular biology, biochemistry, synthetic biology or a related field and 3+ years of industrial experience.
  • Proficiency in fundamental molecular biology techniques such as PCR (Polymerase Chain Reaction), gel electrophoresis, cloning, and DNA sequencing.
  • Experience with synthetic biology approaches including DNA synthesis (e.g. Polymerase cycling assembly) and DNA assembly techniques (e.g. Gibson assembly, Golden Gate assembly).
  • Ability to critically analyze experimental results, interpret data, and draw meaningful conclusions. This includes statistical analysis and data visualization using R, Excel, Python or similar.
  • Proficiency in managing complex research projects, coordinating experiments, and meeting project deadlines. This may involve supervising research assistants or collaborating with interdisciplinary teams.
  • Strong written and verbal communication skills, able to clearly and concisely present data to wide range of stakeholders with varying levels of domain knowledge.
  • Willingness to learn new techniques, adapt to emerging technologies, and apply innovative approaches to problem-solving in molecular biology.

Preferred Candidate Qualifications:
  • Strong understanding of NGS methods, library preparation and data interpretation.
  • Competence in using bioinformatics tools and software for sequence analysis, primer design, and data interpretation. This includes understanding sequence alignments, genome editing tools, and analysis of next-generation sequencing data.
  • Working knowledge of methods for de novo gene synthesis, starting at oligo synthesis.
  • Previous experience with workflow automation using liquid handling systems.

Salary and Benefits:

The annual base salary compensation for this role, if based in California is: $135,000 - $165,000. Compensation may be different in other locations. Final compensation also includes bonus, equity and benefits. Specific offer packages are determined by multiple factors, including candidate skill, experience, expertise, and location.

✓ Healthcare ✓ Dental ✓ Vision ✓ Learning Allowance

✓ 401K ✓ Flexible PTO ✓ Short Term Disability ✓ Fitness Allowance

About The Company:

Founded and led by Dr. Matthew Hill and located in San Carlos, CA, Elegen is well-capitalized by top life science investors, including Andreessen Horowitz, 8VC, and KdT. The company is advised and staffed by leading biotechnology scientists and entrepreneurs, including Dr. Marc Unger, inventor of the Nanoflex™ valve, and former CSO of Fluidigm. Dr. Hill has a PhD from Stanford and a proven track record of advancing innovative technologies from invention to commercial success. Over eight years in his previous role as VP of R&D at a leading molecular diagnostics company, he co-invented and launched five precision molecular diagnostic products, including a best-in-class noninvasive prenatal test used by millions. These products earn more than $350 million per year in revenue and enabled an IPO.

Elegen is an Equal Opportunity Employer.

Elegen provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law. All applicants have rights under the following Federal Employment Laws:
  • Family and Medical Leave Act (FMLA)
  • Equal Employment Opportunity (EEO)
  • Employee Polygraph Protection Act (EPPA)

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