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Principal Research Scientist I Structural Biologist

North Chicago, Illinois, US
Closing date
May 16, 2024

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Academic / Research
Conservation science
Salary Type
Employment Type
Full time
Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Job Description

The Structural Biology Group at AbbVie Headquarters in Lake County, Illinois is seeking a highly motivated scientist to join our Structure-Based Drug Discovery team. The ideal candidate should have extensive hands-on experience in modern X-ray Crystallography techniques with demonstrated leadership in drug design, drug discovery and computational methods of molecular structure analysis. Preferably, the ideal candidate should also have industrial experience and exceptional teamwork, communication and leadership skills. The successful candidate will implement innovative strategies to expand internal structural biology capabilities and contribute to drug discovery projects across the therapeutic area portfolio of AbbVie interests.

Key Responsibilities:

  • Determine X-ray crystal structures of protein-ligand complexes in high throughput modes to solve mechanistic questions and identify strategies for improved molecular designs.

Experience with scientists in areas of Protein Crystallization and Structure Determination to drive construct design, crystallization and structure determination
Provide guidance to crystallization and protein construct design efforts for useful sample preparations
Liaison and coordinate with scientists in areas of Molecular Modeling and Medicinal Chemistry to drive drug design and demonstrate leadership in strengthening our alignment with Computational Drug Discovery team
Initiate adoption of novel technologies which will facilitate structure-based drug discovery at AbbVie based on critical evaluation of the scientific literature
Maintain accurate and timely records of experimental results
Communicate results and interpretative analysis to project teams, and present at internal meetings
Publish in peer-reviewed journals as appropriate and present at external scientific meetings

    • PhD in Chemistry, Biochemistry, Biophysics, or a related field

  • At least 6 years of post-PhD relevant academic or at least 4+ years post-PhD industry experience is required

Proven ability in protein crystallization and structure determination and analysis
Expertise with structure-based drug design strategies including fragment based approaches
Must be detail oriented and meticulous regarding documentation and data management
Ability to work both independently and as part of a highly collaborative, interdisciplinary team
Effective written and verbal communication skills
Ability to work on multiple projects in parallel and rapidly adjust to changing priorities
Demonstrated ability to lead and mentor team members

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
  • The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
  • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
  • This job is eligible to participate in our short-term incentive programs.
  • This job is eligible to participate in our long-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion, consistent with applicable law.

AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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