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Postdoctoral Scientist - Gene Therapy/Stem Cell Biology

Nationwide Children's Hospital
Minerva Park, Ohio, US
Closing date
May 16, 2024

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Academic / Research
Conservation science
Salary Type
Employment Type
Full time

Dr. Sriram Vaidyanathan Lab

We are seeking a postdoctoral scholar for a position to join Dr. Sriram Vaidyanathan's lab at Nationwide Children's Hospital and The Ohio State University. Our lab is in the Center for Gene Therapy at Nationwide Children's Hospital (NCH). The NCH Center for Gene Therapy has a long track record of training leaders in gene therapy, has been the site of the development of the first FDA-approved AAV-mediated gene therapy for neuromuscular disease (SMA). Our lab is focused on the development of genetic therapies for cystic fibrosis.

The development of CRISPR/Cas9 over the past decade has enabled the development of precise genetic therapies for diseases such as sickle cell disease and thalassemia. The Vaidyanathan laboratory is investigating the use of CRISPR/Cas9 based genome editing to treat CF and other diseases affecting the lungs. This position presents the opportunity to further develop new CRISPR/Cas9 based gene editing methods, development of airway stem cell therapies, and study airway stem cell biology.

With guidance from Dr. Vaidyanathan, you will be responsible for leading an independent project that addresses our shared interests and aligns with your career goals. Your responsibilities will include designing and performing experiments, mentoring students/technicians (if desired), analyzing and presenting your results and conclusions, generating figures, and writing and publishing manuscripts.

A background in gene therapy, cystic fibrosis, single-cell analysis or airway stem cell research would be beneficial. The selected candidate must be professional, self-motivated, and dedicated, with strong communication and interpersonal skill sets that fit our team. You will have many opportunities to learn new skill sets, present your work, develop professionally, and contribute to identifying new therapies for pediatric cancers in a dynamic and positive environment.

What Will You Be Doing?
  • Developing gene editing approaches that may durably treat cystic fibrosis and other lung disorders
  • Designing and conducting laboratory-based experiments in cell culture and mouse models
  • Mentoring and training staff and graduate students
  • Collecting experimental data and maintaining an updated lab notebook
  • Collaborating with other researchers at NCH/OSU, nationally, and internationally
  • Critically evaluating and interpreting data and determining next steps
  • Writing and publishing scientific material, including manuscripts
  • Presenting research at regional, national, and international conferences
  • Contributing to grant submissions for external funding

What Are We Looking For?

To fulfill this role successfully, you must possess these qualifications and experience:
  • MD, Ph.D., Pharm.D., or equivalent degree.
  • Desire to pursue a career in biomedical research
  • Technical skills related to cell culture, mouse models and a desire to learn new skills
  • Ability to work independently on laboratory projects
  • Proficiency in scientific writing
  • Excellent communication skills
  • Ability to work in a team

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