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Scientist - Proteomics and Systems Biology (Leonetti Group)

Chan Zuckerberg Biohub - San Francisco
San Francisco, California, US
Closing date
Oct 26, 2023

View more

Academic / Research
Conservation science
Modeling, Biology
Salary Type
Employment Type
Full time
The Chan Zuckerberg Biohub San Francisco ( CZ Biohub SF ) ( ) is an independent nonprofit research institute that brings together three powerhouse universities - Stanford, UC Berkeley, and UC San Francisco - into a single collaborative technology and discovery engine. CZ Biohub SF itself supports some of the brightest, boldest engineers, data scientists, and biomedical researchers to investigate the fundamental mechanisms underlying disease and develop new technologies that will lead to actionable diagnostics and effective therapies. We are guided by our values of scholarly excellence; disruptive innovation; hands-on engineering/hacking/building; partnership and collaboration; open communication and respect; inclusiveness; and opportunity for all.

Our Vision
  • We pursue large scientific challenges that cannot be pursued in conventional environments
  • We enable individual investigators to pursue their riskiest and most innovative ideas
  • The technologies developed at CZ Biohub San Francisco facilitate research by scientists and clinicians at our home institutions and beyond

Diversity of thought, ideas, and perspectives are at the heart of CZ Biohub Network and enable disruptive innovation and scholarly excellence. We are committed to cultivating an inclusive organization where all colleagues feel inspired and know their work makes an important contribution.

The Opportunity

Come join an interdisciplinary team of biologists, technologists, data scientists and engineers!

The Leonetti Group at the Chan Zuckerberg Biohub San Francisco ( ) strives to map how the human cell is built by combining CRISPR, fluorescence microscopy, mass spec proteomics, robotics, software engineering and data science. We build large datasets and use them to develop new algorithms and analyses. For example, our flagship OpenCell project provides a large reference of protein localization and interactions that can be mined and re-used by the entire community for discovery ( ). Our science is fully open-source and published in journals like Science and Nature Methods ( ; )

In our previous OpenCell work, we deployed proteomics at scale to draw a reference map of the molecular interactions that organize the cellular proteome. In our ongoing projects, we are following the cell through perturbations (ex: disease-causing mutations, viral infection) to understand how the entire proteome gets rewired when disease strikes. We are seeking a Scientist - Proteomics and Systems Biology to spearhead our next efforts to develop and apply mass spectrometry methods at scale, and analyze data to extract quantitative insights about cellular responses. This is an exciting opportunity to work at the leading edge of human cell biology, supported by experts in a highly collaborative, open and well-funded scientific environment.

What You'll Do
  • Drive cell biology applications and partner with Biohub's mass spectrometry platform
  • Design proteomics assays for profiling pan-cellular remodeling upon perturbation
  • Develop paired proteomics and metabolomics pipelines for the elucidation of cellular responses and functional interconnections
  • Profile both transformed and stem cell-derived differentiated cell types
  • Quantify cellular responses occurring during disease (infection, neurodegeneration) and identify new cellular mechanisms
  • Be part of a larger team of cell biology and disease experts, microscopists and technology developers
  • Partner with data scientists and software engineers to build pipelines for quantitative data analysis and web portals to share our insights
  • Explain technical concepts to a multi-disciplinary team of biologists, bioengineers, and data scientists at the Biohub
  • Author publications & mentor junior colleagues

What You'll Bring

Essential -
  • PhD in Cell Biology, Systems Biology, Biophysics, or a related discipline
  • At least 5 years of expertise with cell biology and tissue culture models
  • At least 4 years of expertise in mass spectrometry-based proteomics
  • At least 3 years of experience in quantitative data analysis (Python, R, etc....)
  • In-depth technical understanding of mass spectrometry
  • Passion for research and understanding how cells work
  • Enthusiasm for team science and open science
  • Must be team-oriented and have excellent written and oral communication skills

Nice to have -
  • Hands-on experience with mass spectrometry instruments
  • Experience with network analysis

The Chan Zuckerberg Biohub Network requires all employees, contractors, and interns, regardless of work location or type of role, to provide proof of full COVID-19 vaccination, including a booster vaccine dose, if eligible, by their start date. Those who are unable to get vaccinated or obtain a booster dose because of a disability, or who choose not to be vaccinated due to a sincerely held religious belief, practice, or observance must have an approved exception prior to their start date.

  • Scientist I = $100,000 - $137,500
  • Scientist II = $112,000 - $154,000

New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data. Your recruiter can share more about the specific pay range during the hiring process.

What We Provide
  • Resources to disrupt and innovate at the frontiers of our knowledge of biology and disease
  • A collegial and collaborative environment consisting of diverse expertise
  • Existing collaborations within CZ Biohub: Technology Platforms (Bioengineering, Computational Microscopy, Data Science, Genomics & Mass Spectrometry), Infectious Disease , and Quantitative Cell Science
  • Access to collaborators, resources and facilities at our three partner universities (Stanford, UC Berkeley, and UC San Francisco) and at partner organizations in the Bay Area and beyond
  • Competitive compensation and benefits commensurate with the experience


We offer a robust benefits program that enables the important work Biohubbers do everyday. Our benefits include healthcare coverage, life and disability insurance, commuter subsidies, family planning services with fertility care, childcare stipend, 401(k) match, flexible time off and a generous parental leave policy. In addition, we honor our commitment to career development and our value of scholarly excellence through regular onsite opportunities to learn from the world's leading scientists.

The CZ Biohub Network is an equal opportunity employer committed to diversity of thought, ideas and perspectives. We are committed to cultivating an inclusive organization where all Biohubbers feel inspired and know their work makes an important contribution. Therefore, we provide employment opportunities without regard to age, race, color, ancestry, national origin, religion, disability, sex, gender identity or expression, sexual orientation, or any other protected status in accordance with applicable law.

Pursuant to the California Fair Chance Act, we will consider for employment qualified applicants with arrest and conviction records.

Headhunters and recruitment agencies may not submit resumes/CVs through this website or directly to managers. The CZ Biohub Network does not accept unsolicited headhunter and agency resumes. The CZ Biohub Network will not pay fees to any third-party agency or company that does not have a signed agreement with the CZ Biohub Network. #J-18808-Ljbffr

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