Senior Synthetic Biologist (Manager)

Cambridge, Massachusetts, US
Closing date
Oct 8, 2023

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Academic / Research
Conservation science
Salary Type
Employment Type
Full time
About the job Senior Synthetic Biologist (Manager)
Key Responsibilities include:

Bring expertise with versatile gene editing tools allowing knock-in, knock-out, silencing and other genetic manipulation activities

Have an excellent understanding of standard wet lab activities related to engineering, testing and cell culture of mammalian and/or non-mammalian animal cells

Understand intricacies of flow cytometry and be able to apply results to drive experiments forward

Design, produce, and test novel gene editing constructs using molecular cloning and other techniques based on robust, well-controlled scientific experiments (including plasmid digestion, purification, ligation, transformation, and sequencing)

Holding and sharing a strong understanding of in vitro transcription to produce RNA from DNA templates

Holding and sharing a strong understanding of DNA/RNA extraction and downstream analytical assays such as qPCR and RT-qPCR

Assist in development of strategy and methods for primary and iPSC-derived cell culture, transfection, and cell-based assays

Execute and troubleshoot standard protocols, develop and adapt new protocols, and query literature to incorporate additional assays as needed

Stay abreast of new and emerging synthetic biology tools and technologies via frequent literature reviews and periodically attending scientific conferences

Independently plan and execute experiments and mentor team members on facets of experimental design

Document all experimental planning, progress, experimental data and genetic designs in electronic lab notebook, present research design and results to multi-disciplinary teams and leadership

Create and review experimental workflows and collect quantitative measurements for engineered cells including flow cytometry and multi-omics techniques

Manage a team of scientists including bioinformatisticians and synthetic biologists to perform multi-omic discovery, draw meaningful conclusions from data generated and analyzed, and direct synthetic biology workflows from the results

Analyze and distill insight from complex molecular data streams generated by own or other teams

Collaborate frequently with computational biologists, protein engineers and cell biologists to incorporate biological design principles and experimental datasets into the synthetic biology product development pipeline

Test and characterize molecular and cellular system targets using biochemistry, molecular biology and/or genetic approaches

Leverage knowledge of gene editing technologies to contribute scientifically to goals and strategy

Build out synthetic biology lab infrastructure

Develop and perform high-throughput pooled and arrayed functional genomic screens using high-dimensional genomic and cell-based functional readouts such as RNA-seq, ATAC-seq, flow cytometry, and high-content cell imaging in a matrix collaborative setting

Perform on- & off-target genome editing analysis using NGS-based sequencing methods.

The ideal candidate will possess the following qualities & qualifications:

PhD in biological or physical sciences or engineering discipline + 10 years of relevant post-graduate experience, or MS with 15 years of relevant post-graduate research experience.

Hands-on experience in genome editing experiments and analysis

Experience using bioinformatic and molecular biology software to select gRNA and design plasmid constructs

Solid cell and molecular biology concepts on mammalian or non-mammalian animal genome structure and organization and the control of gene expression and DNA repair

Experience in animal cell culture and functional assay development

Track record of publication in peer-reviewed journals or scientific conferences

Excellent communication and presentation skills to both technical and non-technical colleagues

Cross-functional work experience and highly collaborative attitude

Flexibility and adaptability to changing priorities in a fast-paced, start-up environment

Demonstrated strong competence, hands-on experience and experimental design with a multitude of research techniques and methodologies in related field(s)

Manages, mentors and motivates staff

Applies conceptual knowledge to drive individual and group performance

Navigates change and establishes high performance standards

Sets appropriate timelines and expectations for self and team members

Sets direction in ambiguous and challenging situations

Applies scientific foundation to implement and drive change

Becomes knowledge resource for complex projects

Strong ability to identify and implement clear objectives for projects and team members as appropriate

Demonstrated ability to multitask, work in a dynamic and diverse project environment, and adapt to changing priorities

Ability to perform multiple technical tasks independently

Strong organizational skills and ability to maintain a detailed electronic laboratory notebook

Ability to work independently and as a team member

Strong oral and written communication skills

Ability to record and analyze data and interpret acceptability of data results

High degree of computer literacy and experience with Microsoft Office Suite (Word, Excel, PowerPoint, Project)

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