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Specialist - Molecular Biology & Proteomics (Krogan lab, UCSF)

University of California - San Francisco
San Francisco, California, US
Closing date
Sep 19, 2023

View more

Academic / Research
Conservation science
Salary Type
Employment Type
Full time
Application Window

Open date: June 2, 2023

Next review date: Sunday, Jul 2, 2023 at 11:59pm (Pacific Time)

Apply by this date to ensure full consideration by the committee.

Final date: Monday, Dec 2, 2024 at 11:59pm (Pacific Time)

Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.

Position description

Specialist - Molecular Biology & Proteomics (Krogan lab, UCSF)

Your work will focus on mapping protein interactions and signaling networks for complex biological problems on cross-disciplinary projects.

This role is an excellent opportunity to learn several valuable, cutting-edge techniques in cell and molecular biology, as well as proteomics, while working with a dynamic and interdisciplinary research team. You will generate and characterize cell lines and/or iPSC lines expressing affinity-tagged proteins of interest, perform affinity purifications, and proximity labeling of proteins and their interactors for mass spectrometry analysis to study protein-protein interactions. You will learn and apply different cellular, molecular and biochemical assays to validate these findings. The candidate will also have the opportunity to develop and implement new protocols for mass spectrometry-based proteomics experiments.

The Krogan Lab is a highly dynamic and collaborative laboratory focusing on the molecular networks underpinning infectious disease, carcinogenesis and neurological disorders.

Our ideal applicant is a problem solver with a positive attitude, excellent organizational and interpersonal skills, and the ability to learn and implement methodology efficiently. Candidate's CV and/or cover letter must state basic qualifications (or if pending) upon submission. Candidates must meet all qualifications by the time of hire.

Required Qualifications:

    Jr. Specialist rank: Bachelor's degree in biological sciences or an appropriate scientific field.
    Assistant Rank: Master's degree, or Bachelor's degree and 3 years of work experience in biological sciences or an appropriate scientific field.
    Associate Rank: Master's degree, or Bachelor's degree and 5-10 years of work experience in biological sciences or an appropriate scientific field.
    Full Specialist: PhD. or 10 years of work experience in biological sciences or an appropriate scientific field.
    Experience in the essential molecular biology techniques of molecular cloning, PCR, and western blotting.
    Experience in cell/tissue culture.
    Able to work independently and meet deadlines; recognize and resolve problems while maintaining a high level of organization.
    Effective verbal and written communication skills to interface with the team to review and analyze the results.
    Demonstrated experience in Microsoft Word and Excel

    Preferred Qualifications:

      Experience generating new cell lines and characterizing them.
      Experience culturing iPSCs and iPSC-derived cells.
      Experience transfection or viral transduction.
      Experience with affinity purifications of proteins.
      Experience with CRISPR/gene editing techniques
      Experience with immunoprecipitation.
      Experience in preparation of samples for mass spectrometric analysis.
      Experience in fluorescence microscopy.
      Experience with mass spectrometry data.
      Experience with managing large datasets and/or databases.
      Experience with statistical data analysis.

      To apply, please submit a CV, cover letter, and the contact information for 2 references to

      See Table 24B for the salary range for this position. A reasonable estimate for this position is $49,000 -$173,900.

      Application Requirements

      Document requirements
      • Curriculum Vitae - CV must clearly list current and/or pending qualifications (e.g. board eligibility/certification, medical licensure, etc.).

      • Cover Letter

      • Statement of Research (Optional)

      • Statement of Teaching (Optional)

      • Statement of Contributions to Diversity - Please see the following page for more details: Contributions to Diversity Statement


      • Misc / Additional (Optional)

      Reference requirements
      • 2 required (contact information only)

      Campus Information

      As a condition of employment, you will be required to comply with the University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy found here:

      UC San Francisco seeks candidates whose experience, teaching, research, or community service that has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.

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