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Scientist, Molecular Biology, Antibody Discovery

Montgomery Village, Maryland, US
Closing date
Sep 22, 2023

View more

Academic / Research
Informatics / GIS
Salary Type
Employment Type
Full time
Summary of the group

The Biologics Engineering (BE) department at AstraZeneca is constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We're using our expertise in biologics engineering to enable novel therapeutic approaches to Oncology, Respiratory, Inflammatory, Cardiovascular and Infectious disease. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore new and exciting technologies.

This opportunity

The Department of Biologics Engineering in Gaithersburg, MD is seeking a talented and highly motivated Scientist to utilize and enhance our Antibody discovery platform. The successful candidate will aide in discovery of antibodies for various therapeutic programs and provide capability improvements on our technology platform. We are seeking a candidate with expertise in molecular biology for antibody engineering that is excited by research at the interface between technology and biology. The candidate will operate independently and in collaboration with a diverse group of scientists to advance pipeline projects and further technological innovations. The selected individual will be a well-organized and a highly productive bench scientist that can design and execute experiments efficiently, as well as analyze, interpret and present data to multidisciplinary project teams.

Required Education/Experience

B.S. in molecular biology or other related discipline with 5+ years experience


M.S. in molecular biology or other related discipline with 2+ years experience

Main Job Responsibilities


Routinely generate large antibody libraries for display technologies

Perform emulsion PCR and DNA prep for subcloning of libraries or for single constructs

Design primers, troubleshoot Sanger sequencing, analyze and align sequences

Transfect, express, and purify antibodies in small scale

Characterize antibodies for affinity using BLI, epitope binning and binding in ELISA

Run lab automation for high-throughput assays and coordinate with automation team

Required skills


Extensive background in advanced molecular biology techniques, including design and execution of molecular cloning schemes for library construction, PCR, and recombinant antibody expression

Experience with bioinformatics and sequence alignment software

Experience with laboratory automation to prepare and conduct biochemical assays

Experience with advanced features of MS Excel and graphing software for data analysis

Ability to draft, execute and record experiments in a timely manner and maintain an excellent laboratory notebook

Proven experience to troubleshoot, optimize and execute experiments independently

Ability to work independently and as part of a team

Desired skills


Expertise in high-throughput assays for antibody characterization, such as 384-well ELISA

Experience in Next Generation Sequencing and Sanger sequencing

Experience in antibody development in a biotech/pharma setting

Special Skills / Abilities / Knowledge / Behavioral Competencies

Strong communication skills are highly desirable. The individual should also be self-motivated, embrace new technologies and have demonstrated an ability to work within teams.
Salary: Negotiable

This employer is a corporate member of myGwork - LGBTQ+ professionals, the business community for LGBTQ+ professionals, students, inclusive employers & anyone who believes in workplace equality.

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