- Develop and utilize chemical biology methods for target identification, target engagement, and selectivity profiling studies to elucidate the mechanism of action of small molecule drug candidates.
- Conduct research dealing with the understanding of human diseases and the improvement of human health, engage in clinical investigation, and research and development, in the area of chemoproteomics.
- Design and apply chemical probes for cellular protein activity profiling.
- Conduct small molecule probe experiments in mammalian cell culture and tissue homogenate and analysis of these samples using a variety of protein detection methods including in gel fluorescence, Western blotting, and mass spectrometry.
- Publish results in chemical biology journals and present research at both internal and external meetings.
Ph.D. degree (or foreign equivalent) in Chemical Biology, Biochemistry, or a directly related field and 4 years of research experience in the field of Chemical Biology and MS-based proteomics or chemoproteomics which may be gained during graduate studies.
Experience must include:
4 years of experience with each of the following:
- Hands-on experience in proteomics sample preparation and operating modern LC/MS systems.
- Data analysis and interpretation.
- Working knowledge of protein biochemistry and familiarity with cell culture procedures, including siRNA knockout or stable and transient overexpression by lentiviral transduction and plasmid transfection.
- Techniques used in chemical biology, including click chemistry, affinity chromatography, immunoprecipitation, gel electrophoresis, and western blotting.
- Working knowledge of mass spectrometry based proteomics software, including Proteome Discoverer or MaxQuant.
- Liquid-liquid phase separation and imaging experience with confocal and brightfield microscopy, immunofluorescence, and quantification of puncta by software programs.
1 year of experience with:
Activity based protein profiling, including the use of small molecule probes to identify protein targets.
All your information will be kept confidential according to EEO guidelines. Why Biogen?
Our mission to find therapies for neurological and rare diseases is a unique focus within our industry and this shared purpose is what connects us as a team. We work together to overcome obstacles and to follow the science. We are resilient as we strive to make an impact on our patients' lives and on changing the course of medicine. Together, we pioneer. Together, we thrive.
At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.
All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.