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Principal Scientist - Computational Biology (US-REMOTE)

South San Francisco, California, US
Closing date
Sep 30, 2023

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Academic / Research
Informatics / GIS
Modeling, Biology
Salary Type
Employment Type
Full time

If you feel like youre part of something bigger, its because you are. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies. We are global collaborators who achieve togetherresearching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. Its time for a career you can be proud of.

Principal Scientist - Computational Biology
What you will do

Lets do this. Lets change the world. The Clinical Biomarkers & Diagnostics (CBD) department at Amgen is looking for a highly motivated Computational Biologist with expertise in clinical bioinformatics, biomarker development, assay development, ML algorithms & data science, statistical modeling, handling clinical data sets and a background in biology and computational sciences. This is a highly visible, individual contributor role. Therefore, preference will be given to candidates with prior experience within matrix environments and those having the expertise to support clinical development. In this vital role you will:
  • Support the development of clinical biomarkers and diagnostics for Amgen programs through the formulation and implementation of biomarker data analysis
  • Perform assessment of biochemical coverage, patient stratification, indication selection in Amgens early and late clinical development programs and discovery of clinical insights at asset and portfolio levels through the application of knowledge discovery and data mining techniques
  • Develop translational analysis methods to enable the analysis of NGS data/Epigenomics assays/single-cell assays from clinical trials
  • Develop translational informatics analysis workflows in a high-content, multi-omics, multi-modal data domain encompassing genomics, transcriptomics, proteomics, metabolomics and epigenomics domains
  • Develop innovative best-practices for the next generation of clinical bioinformatics, such as the utilization of ctDNA-derived tumor burden as a prognostic biomarker/surrogate end point
  • Work with biologists, especially in immuno-oncology, to leverage information on targeted biological pathways along with development of computational algorithms to manage and mine internal and external genomics and other high-content databases
  • Provide leadership and expertise to the function in the areas of algorithm development, bioinformatics, data integration & management, visualization, analysis, and presentation
  • Represent the clinical biomarkers & diagnostics team in some Amgen program/portfolio teams as a biomarker analysis lead
  • Participate in diagnostics assay and vendor evaluation and selection by providing inputs from computational perspective
  • Interface cross-functionally with the early development teams, assay laboratories, in-vitro diagnostics and biomarker representatives
What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a strategic, motivated, hands-on, data and science-driven leader with these qualifications.
Basic Qualifications:
Doctorate degree and 2 years of scientific/clinical development experience


Masters degree and 5 years of scientific/clinical development experience


Bachelors degree and 7 years of scientific/clinical development experience
Preferred Qualifications:
  • PhD in Computational Biology, Bioinformatics, Mathematics, Statistics, Computer Science, Bioengineering or a related field with expertise and experience in drug development, biomarkers and diagnostics
  • Working knowledge of bioinformatics, applied mathematics and/or statistics to analyze multi-modal, multi-dimensional and large-scale biological data sets such as those from next-generation sequencing DNASeq, RNASeq and proteomics assays
  • Working knowledge of platforms and readouts used for the assessment of clinical biomarkers including flow cytometry, IHC, NGS, immunoassays, imaging and transcriptional profiling assays
  • Ability to translate biological and medical questions into analytical models providing measurable results
  • Working knowledge and experience of Machine Learning and AI technologies; Experience of applying ML/AI in clinical trial setting is a plus
  • Experience with Python and/or R and associated data-processing and aware of good programming practices
  • Excellent communicator with the ability to distill complex issues and clearly articulate solutions with dynamic social skills, situational awareness and the ability to influence, motivate, and work in a multidisciplinary setting
What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well-being.

The annual base salary range for this opportunity in the U.S. is $153,581 - $178,350. The annual base salary range for this opportunity based in South San Francisco is $153,628 - $184,290.

In addition to the base salary, Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:
  • Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
  • Stock-based long-term incentives
  • Award-winning time-off plans and bi-annual company-wide shutdowns
  • Flexible work models, including remote work arrangements, where possible
Apply now
for a career that defies imagination

Objects in your future are closer than they appear. Join us.
Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.

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