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GPCR Drug Discovery Biologist (Senior Scientist II or Principal Scientist I)

Chelsea and Clinton, New York, US
Closing date
Jun 28, 2023

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Academic / Research
Conservation science
Salary Type
Employment Type
Full time
We are seeking a highly motivated and experienced in vitro biologist/molecular pharmacologist to lead GPCR drug discovery efforts on our Therapeutics team. The successful candidate will have a proven track record driving GPCR drug discovery programs from target validation through lead optimization. We are looking for a passionate scientist who can successfully work in multi-disciplinary teams to advance drug discovery projects.
Our drug discovery and early clinical development team includes a cross-functional group of scientists and drug developers with experience working on all common target classes and therapeutic areas. The group is supported by more than 100 software developers and engineers as well as a large-scale compute infrastructure to apply our proprietary physics-based drug design and optimization platform. Several programs we have worked on have achieved Development Candidates, including progression to clinical development and FDA approval. You can view our entire pipeline of wholly-owned programs and collaborations here.
Who will love this job:
  • An in vitro biologist/molecular pharmacologist with success in driving GPCR drug discovery programs
  • An independent scientist excited to help guide strategy around GPCR drug discovery efforts
What you will do:
  • Lead pharmacology efforts to support the advancement of GPCR drug discovery projects from hit ID through development candidate selection
  • Independently manage CRO scientists in the design, development, and implementation of in vitro assays for the advancement of GPCR projects
  • Contribute to the identification of GPCR targets suitable for Schrodinger's drug discovery pipeline
  • Guide KOL interaction and research strategy for exploratory and early stage GPCR drug discovery efforts
What you should have:
  • PhD or MS in pharmacology, biochemistry, or related field with a high level of expertise in GPCR pharmacology
  • At least three years of experience in pharmaceutical or biotechnology industries (minimum five years experience for an MS degree)
  • Demonstrated success applying cellular and molecular pharmacology in vitro biology tools to support and advance drug discovery programs with an emphasis of GPCR drug discovery
  • In depth knowledge of GPCR molecular pharmacology with specific expertise characterizing mechanism of action, potency, and efficacy of hits and leads
  • Exposure to structured-guided GPCR drug discovery desired
  • Understanding of in vivo pharmacology desired
  • Excellent communication and organizational skills

Pay and perks:

Schrödinger understands it's people that make a company great. Because of this, we're prepared to offer a competitive salary, stock options, and a wide range of benefits that include healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program. We have catered meals in the office every day, a company culture that is relaxed but engaged, and over a month of paid vacation time. Our Administrative and Human Resources departments also plan a myriad of fun company-wide events. New York is home to our largest office, but we have teams all over the world. Schrödinger is honored to have been selected as one of Crain's New York Best Places to Work for the past three years running.

Estimated base salary range: $130,000 - $180,000 (NYC only). Actual compensation package is dependent on a number of factors, including, for example, experience, education, degrees held, market data, and business needs. If you have any questions regarding the compensation for this role, do not hesitate to reach out to a member of our Strategic Growth team.

Sound exciting? Apply today and join us!

As an equal opportunity employer, Schrödinger hires outstanding individuals into every position in the company. People who work with us have a high degree of engagement, a commitment to working effectively in teams, and a passion for the company's mission. We place the highest value on creating a safe environment where our employees can grow and contribute, and refuse to discriminate on the basis of race, color, religious belief, sex, age, disability, national origin, alienage or citizenship status, marital status, partnership status, caregiver status, sexual and reproductive health decisions, gender identity or expression, sexual orientation, or any other protected characteristic. To us, "diversity" isn't just a buzzword, but an important element of our core principles and key business practices. We believe that diverse companies innovate better and think more creatively than homogenous ones because they take into account a wide range of viewpoints. For us, greater diversity doesn't mean better headlines or public images - it means increased adaptability and profitability.

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