Research Principal Scientist/Associate Director : Myeloid Lead Innate Biology

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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine?

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.

OBJECTIVES/PURPOSE

The Cell Engager team of the Oncology DDU is seeking a highly motivated and experienced in vitroImmunologist or cellular biologist with experiemce in Myeloid Biology to join a very collaborative and dynamic team to help advance the cell enagager pipeline programs. This position will be responsible for establishing the Myeloid strategy, evaluation of various cell enagager molecules linked to COBRA and Innate biology. As a potential member of the CE Leadership Team, the candidate will focus on the development of in vitro strategies, and screens that provide framework for the evaluation of various Immune Engagers. The successful candidate must have in-depth knowledge of T cell Biology as well as immune dysfunctional mechanisms in the tumor microenvirontment to evaluate potential mechnisms of resistance of Immune cell engagers. The successful candidate must have a strong foundation in cancer biology, redirected T cell immunity and hands-on experience in their evaluation in pre-clincal in vitro systems and track record of success in IO drug discovery. The candidate must have expeinece working with cross functional teams in a matrixed environment and will be responsible for providing key technical knowledge to a project team to move candidates through lead selection and IND. The individual will collaborate and demonstrate effective communication and documentation of results with key stakeholders in IOI, C2H, Global Biologics, DSRE, DMPK, Translational teams and CTI. Ideal applicant will be team-oriented, possess excellent communication and organizational skills.

ACCOUNTABILITIES

• Provide leadership, scientific knowledge, and expertise in antibody and TCE evaluation, across multiple in vitro models
• Apply strong knowledge of Cancer Immunology and Multispecifics and how to develop therapeutic intervention strategies.
• Help establish new directions and help mobilize the team through crisp communication of strategic vision and program goals.
• Contribute to the preparation/editing/review of documents for regulatory submission (i.e., study reports, IB's, IND's)
• Demonstrate collaborative well-developed knowledge of other departments and how they function together
• Demonstrate either or both: exceptional project management skills or broad recognition for in-depth expertise in a scientific discipline
• Design and direct research strategy and activities to meet program goals; provide leadership, timelines and contingency plans
• Manage a matrixed based team to deliver on critical cell based assays, isolation of VD1 cells
• Frequent contact with all personnel at several management levels
• Collaborate with other departments, being a scientific authority within discipline
• Be a senior company / project representative at external conferences, or business meetings
• Strong managerial experience leading scientists (RAs through PhD level Scientists)
• Determine methods on new assignments; make strategic recommendations on projects; greater demonstrated independence; may manage junior staff
• Engage in new idea generation and prioritization of tumor antigen selection
• Identify and integrate technologies that improve or expand the ability to assess the MoA of novel immunomodulatory agents
• Establish and manage relationships with external research collaborators and CROs for cell based and translational assays a required
• Ability to take the initiative, planning and implementing work but also proven ability to work as part of a team, engaging constructively with colleagues at all levels to deliver objectives.
• Flexible, pragmatic and practical, highly motivated to ensure that studies meet challenging timelines and able to propose practical, compromise solutions to problems
• Demonstrates theoretical knowledge of cell engager platforms and Myeloid Biology
• Keeps current with emerging trends in immne cell engagers for application in cancer therapy
• Able to clarify requests and provide suggestions and put data into context especially in context of assay design and quality of data
• Demonstrates in-depth technical knowledge within various assay development platforms
• Indepently investigates new immunological techniques, that can be applied to team projects
• Serves as the in vivo immunobiology lead on projects provinding key scientific feedback to advance programs in a matrixed environment.
• Lead and manage via a matrixed structure
• Independently manages own workload
• Scientifically independent
• Provides information to project teams to influence direction, align with departmental goals and/or business
• Conducts scientific presentations to internal audiences
• Collaborates with others across sites, and acts as scientific resource for in vitro pharmacology
• Participates in and supervises external interactions and collaborations with companies and academic research groups and potential collaborator
• Expected to participate in new idea generation
• Strives towards expanding scientific knowledge in immunology
• Receives high level instructions on work; determines methods on new assignments; demonstrated greater independence; may manage interns

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:

• PhD 6+ years industry experience, MS with 10+ BS with 12+ years experience (industry experience strongly preferred), Immunology, Immuno-oncology, T cell biology, Myeloid Biology
• Current knowledge of oncology research, drug discovery and development with an emphasis on immune cell activation, T cell retargeting platforms, protocols as well as markers for anti-tumor efficacy
• Experience leading projects in early drug development is required
• Good understanding of Immunology and experience with Innate biology preferred
• Extensive experience with biologics is a must (Antibodies, ADCs, Cell therapeis etc)
• Experience leading projects and working with cross functional teams is required
• A demonstrated track record of independent critical thinking and scientific achievement
• Self-motivated, collaborative with excellent time management and organizational skills Proficient in the isolation, culture, and functional characterization of primary human immune cells.
• Excellent team player with a can-do attitude with an ability to thrive in a dynamic "biotech- like" environment and work in cross-functional project teams
• Excellent written and verbal communication skills.

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

WHAT TAKEDA CAN OFFER YOU:

• 401(k) with company match and Annual Retirement Contribution Plan
• Tuition reimbursement Company match of charitable contributions
• Health & Wellness programs including onsite flu shots and health screenings
• Generous time off for vacation and the option to purchase additional vacation days
• Community Outreach Programs

Base Salary Range: 143,500.00 to 205,000.00 Employees may also be eligible for Short Term and Long-Term Incentive benefits. Employees are eligible to participate in Medical, Dental, Vision, Life Insurance, 401(k), Charitable Contribution Match, Holidays, Personal Days & Vacation, Tuition Reimbursement Program and Paid Volunteer Time Off.

The final salary offered for this position may take into account a number of factors including, but not limited to, location, skills, education, and experience.

Empowering Our People to Shine

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EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time