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Scientist, Discovery Biology

Employer
Entrada Therapeutics
Location
South Boston, Massachusetts, US
Salary
Competitive
Closing date
Jun 13, 2023

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Sector
Academic / Research
Field
Conservation science
Discipline
Energy, Biology
Salary Type
Salary
Employment Type
Full time
The Organization

What's happening at Entrada Therapeutics? Our mission is to transform the treatment of devastating diseases and improve patients' quality of life using intracellular biologics. Leveraging our proprietary Endosomal Escape Vehicle (EEV)™ platform, we are creating and advancing a diverse pipeline of oligonucleotide, enzyme, protein, and peptide programs to efficiently target and engage underlying drivers of diseases.

Our novel approach to drug design and delivery addresses current challenges associated with both large and small molecule therapeutics and represents a fundamental advancement in the field of intracellular biologics.

We're a tight-knit team of experts and leaders in both therapeutics development and rare disease and are excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Perfect Fit

You should be versatile, self-motivated, and looking forward to rolling up your sleeves, as you will be involved in all aspects of the development of the delivery platform for antisense oligonucleotides and small interfering ribonucleotide therapeutics. You will support our drug discovery team as we develop oligonucleotide-based pipelines to treat some of the world's most challenging diseases.

The Opportunity

In this role you will be responsible for designing, screening, and optimizing oligonucleotide constructs for DNA and RNA targets. You will be developing and executing cell-based assays for validating biological activity of oligonucleotide therapeutics in vitro, along with processing and analyzing samples from in vitro and in vivo PK/PD studies. You will also work on the exploration of new modalities and new targets to expand the scope of EEVTM delivery platform. In tandem, you will prepare SOPs and other reports for assay development and validation. During internal and external meetings, you should be ready to interpret and present research data and findings, you will also contribute to patents, reports and scientific publications.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:
  • Humanity - We genuinely care about patients and about one another.
  • Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
  • Creativity - We are creative problem solvers.
  • Collaboration - We are more than the sum of our parts.
  • Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:
  • Ph.D. in biochemistry, biology, or a related field along with 0-3 years of post-degree experience laboratory research experience in industry or academic setting
  • Strong background in drug-delivery technologies, with a focus on oligonucleotides therapeutics
  • Hands-on experience in cellular and molecular biology techniques (cell culture, DNA/RNA extraction, RT-PCR, qPCR, Western Blot)
  • Experience performing SAR is preferred
  • Ability to work independently and collaborate with interdisciplinary team with excellent written and oral communication skills

The Perks

By becoming a team member here at Entrada, you'll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, paternity leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.
Third Party Staffing Agencies
Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

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