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Team Leader & Principal Scientist, Cell Biology for Cardiovascular Research

Biomarin Pharmaceutical Inc.
San Rafael, California, US
Closing date
Jun 18, 2023

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Who We Are

For more than two decades, going our own way has led to countless breakthroughs, bettering the lives of those suffering from rare genetic disease. In 1997 we were founded to make a big difference in small patient populations. Now we seek to make an even greater impact by applying the same science-driven, patient-forward approach that propelled our last 25 years of drug development to larger genetic disorders, as well as genetic subsets of more common conditions. Through our unparalleled expertise in genetics and molecular biology, we will continue to develop targeted therapies that address the root cause of the conditions we seek to treat. Applying our knowledge to make a transformative impact is not just a calling, but an obligation to those who will benefit most. The end goal has always been better lives and now we can reach more.

And the more people we reach, the more our impact can grow. We transform lives through genetic discovery.

Our Culture

Our desire to make a positive impact on our patients extends to our employees and BioMarin is committed to fostering an inclusive environment where every person feels seen, valued, and heard - so employees can thrive in all areas of their lives, in and outside of work. We seek to provide an open, flexible, and friendly work environment to empower people and to provide them with the ability to develop their long-term careers. Ultimately, we want to be an organization where people enjoy coming to work and take pride in our efforts to help patients.

BioMarin's Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class or best-in-class therapeutics that provide meaningful advances to patients. Come join our team and make a meaningful impact on patients' lives.

The Cardiovascular (CV) Research group at BioMarin is seeking a Principal Scientist (Team Lead/Director-level role) with extensive experience researching genetic/inherited cardiac diseases using a broad range of cell-based models, particularly in the context of evaluating novel therapeutic approaches.

The Principal Scientist will lead the research and early development of programs targeting genetic heart disease/genetic cardiomyopathies, including the formation of cross-functional program teams and, in partnership with the CV team, building short- and long-range plans and establishing key go/no-go decision-making criteria. In addition to leading an early program team, the Principal Scientist will be a key scientific driver in the group, interfacing with program teams in developing novel therapeutics for inherited heart diseases and playing a leadership role in helping to set the strategic direction for BioMarin's interest in genetic cardiac diseases, including the assessment of new target/therapeutic concepts and the evaluation of potential business development opportunities. The Principal Scientist will lead a team of several direct reports.

The successful candidate will have a strong background in cardiovascular physiology, with demonstrated experience in the application of novel therapeutic paradigms for genetic heart diseases. Experience with cardiomyocyte excitation-contraction coupling and cardiac electrophysiology is a must.

The successful candidate will have experience providing context of findings to senior management and offering insights to inform continued clinical development of programs for genetic cardiomyopathies. The candidate will communicate, publish, and present scientific data and conclusions, along with their potential translatability to humans, to project teams, external collaborators, and the scientific community.

  • Develop novel programs based on innovative, ground-breaking discoveries that could lead to new, high-impact therapeutic opportunities for patients.
  • Lead a cross-functional pre-clinical research team in the development of novel therapeutics for genetic cardiomyopathies.
  • Direct research and publish findings in high-impact journals and present research at major conferences.
  • Effectively partner with the program team, other scientists and the Research and Early Development leadership team to develop and execute on the programs' strategic plans.
  • Present program data at a range of internal forums, including Research Seminars and Leadership Team governance forums.
  • Provide senior scientific leadership and guide the strategic direction of the company's efforts in the Genetic Cardiomyopathy therapeutic area, including developing and evaluating new internal and external therapeutic opportunities
  • Manage, mentor and guide a team of scientists
  • Review and contribute to study synopses, protocols, study reports and regulatory documents
  • Collaborate with various BioMarin functions, CROs, university or analytical laboratories, business partners, as necessary to ensure appropriate/timely progression of projects
  • Participate in multi-disciplinary drug development teams and may lead sub-teams
  • Excellent written and verbal communication skills
  • Ability to build/foster productive cross-functional collaborations both within and external to BioMarin

  • Required: Ph.D. with strong experience in cardiovascular research and cardiac myocyte function (including adult cardiomyocytes and human iPSC-derived cardiomyocytes).

Education & Experience Level:

  • PhD or equivalent relevant experience plus 10+ years industry experience

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.

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