Research Scientist I : IO and Cancer Biology (In vivo and Exvivo)

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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine?

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.

OBJECTIVES/PURPOSE

The Cell Engager team of Takeda's Oncology Drug Discovery Unit is looking for an in vivo lab-based scientist to join a collaborative and dynamic team. Contribute to pre-clinical projects by developing well-defined in vivo experiments and projects within oncology research. The candidate should have a foundation in immunology and/or cancer biology. The candidate must have a strong foundation in in vivo oncology models and will be responsible for critical path activities with demonstrated in vivo skills in immuno-oncology drug discovery. The candidate will play a critical role in supporting key pipeline programs tied to various immune engaging mechanisms. The position will require the individual to be hands-on. The individual will collaborate and demonstrate effective communication and documentation of results with key stakeholders in the ODDU (IOI, C2H) GB, DSRE, DMPK, Translational teams and CTI. Provides theoretical/conceptual input to the design, development and execution of well-defined projects within the area of expertise.

ACCOUNTABILITIES

Independently design and complete in vivo experiments with a primary focus on efficacy, PK and MOA studies in a range of models (syngeneic, xenograft)
Perform standard and complex in vivo procedures, such as dosing all routes, tissue necropsy, and tumor inoculation and measurements
Analysis, interpretation, and presentation of data to important partners, and play an active role in the subsequent scientific discussions leading to important decisions and program-ensuring next steps
Initiate investigation of new experimental approaches to specific problems using scientific theory, data from external partners, and technical literature
Help with external collaborations with CROs and establish new protocols
Ability to multi-task effectively and prioritize workload
Prepares and presents comprehensive technical or project reports and formal presentations
Maintain laboratory notebooks and follow laboratory practices in compliance
Contributes to IND report and documentation.
Demonstrates in-depth technical in vivo knowledge
Able to clarify requests and provide suggestions and put data into context especially in context of study design and quality of data
Serves as the in vivo lead on projects providing key scientific feedback to advance programs in a matrixed environment.
Assist with external collaborations with CROs
Independently manages own workload
Scientifically independent
Conducts scientific presentations to internal audiences
Collaborates with others across sites, and acts as scientific resource for in vitro pharmacology
Participates in and supervises external interactions
Strives towards expanding scientific knowledge in immunology
Receives high level instructions on work; determines methods on new assignments; demonstrated greater independence; may manage interns

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:

PhD in Immunology or Cancer Research (no postdoctotal experience is required);
MS with 6+ years experience or BS with 8+ years experience with previous industry experience strongly preferred
Proficiency with in vivo efficacy rodent models, including mouse syngeneic, xenograft and PDX models is required.
Strong experimental skills, including mammalian tissue culture, in vivo model development, drug administration by multiple routes (IV, SQ, IP, PO, RO), and blood/tissue collection. Cell culturing and maintaining human tumor cell lines and primary human cells with best practices in tissue culture is critical
Initiates investigation of new experimental approaches to specific problems using scientific theory and technical literature
Identifies, plans and executes well defined scientific projects
Uses defined practices and theoretical knowledge to perform analysis, interpret results and determine appropriate action
Utilizes relevant information, technology and resources, contributing to complex team problem resolution and objectives
Interprets results of complex experiments
Hands -on experience with multi-color flow cytometry, ELISA, MSD and other standard cell based and non-cell based biochemical assays is required.
Use of scientific databases and application for data management and data analysis (Graph Pad Prism, Soft Max Pro, Office 365, FlowJo etc)
Excellent written and verbal communication skills,
Excellent team player with a can-do attitude with an ability to thrive in a dynamic "biotech- like" environment and work in cross-functional project teams
Innovative and critical thinking
Self-motivated, collaborative with excellent time management and organizational skills
Takeda's high-engagement culture is an important factor in our success; we seek team members who will contribute to and further strengthen that culture.

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

WHAT TAKEDA CAN OFFER YOU:

401(k) with company match and Annual Retirement Contribution Plan
Tuition reimbursement Company match of charitable contributions
Health & Wellness programs including onsite flu shots and health screenings
Generous time off for vacation and the option to purchase additional vacation days
Community Outreach Programs

Base Salary Range: 102,200.00 to 146,000.00. Employees may also be eligible for Short Term and Long-Term Incentive benefits. Employees are eligible to participate in Medical, Dental, Vision, Life Insurance, 401(k), Charitable Contribution Match, Holidays, Personal Days & Vacation, Tuition Reimbursement Program and Paid Volunteer Time Off.

The final salary offered for this position may take into account a number of factors including, but not limited to, location, skills, education, and experience.

Empowering Our People to Shine

Discover more at takedajobs.com

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EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MAWorker Type

EmployeeWorker Sub-Type

RegularTime Type

Full time