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Assoc. Director, Genomics Computational Biology

Montgomery Village, Maryland, US
Closing date
May 28, 2023

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Academic / Research
Informatics / GIS
Genetics, Biology
Salary Type
Employment Type
Full time
Associate Director, Genomics Computational Biology, Translational Medicine

Gaithersburg, MD

We are seeking an Associate Director to lead our computational biology efforts within the Genomics team of Early Oncology Translational Medicine at AstraZeneca. The Gaithersburg Genomics team works in close collaboration with our Global Genomics teams in Waltham, MA and Cambridge, UK. This collaboration leverages cutting edge genomics technologies to develop the next generation of diagnostics, therapeutics, and treatment strategies that will improve the lives of cancer patients. The computational biology Associate Director will support translational research by analyzing various genomics sequencing data from WTS, WES and WGS to single cell applications (e.g., RNA-Seq, ATAC-Seq, CITE-Seq) for technology evaluation, development, and implementation. The ideal candidate will coordinate and liaise between TM Genomics and AZ Oncology Data Science & AI functions to insure seamless communication between the Genomics and DS&AI teams. Biological subject matter will encompass many areas of focus in Oncology, including tumors drivers, drug resistance, immuno-oncology, tumor-targeted delivery, cell therapy, and epigenetics. The ideal candidate will have proven academic and/or industry experience in the computational oncology field. This role will create impact to the wider AZ oncology community, and to our patients through the discovery of new biomarkers that inform drug combinations and patient selection strategies, discovery of novel oncology targets, and deepen knowledge of cancer biology and evolution.


* Perform bioinformatics analyses of varied genomic datasets (including but not limited to bulk genomic assays and single cell assays) generated from clinical and pre-clinical samples
* Perform multi-modal (multi-omic) genomics analyses that require the integration of multiple types of single-cell genomics and spatial omics data or the integration of single-cell and bulk genomics data.
* Work closely with Genomic scientists on experimental designs for evaluating new assays and/or instrumentation
* Coordinate with Oncology Data Science and AI on implementing new instrumentation or assays
* Support the design of novel experimental strategies for genomics data generation from a variety of clinical sample types.
* Develop and apply analytical methods and pipelines for routine internal usage and evaluate publicly available analytical tools.
* Proactively engage in knowledge sharing and peer support, including training bench scientists to build expertise in computational biology tools.

Essential requirements for the role

* PhD in relevant field of computational biology, bioinformatics, systems biology, or oncology data science and experience in either: bulk and single-cell RNA sequencing technologies or cancer genomics/proteomics.
* Proficiency analyzing and interpreting data from multiple 'omic platforms (NGS sequencing, transcriptomic, epigenetic, proteomic etc.).
* Expertise in the analysis of genomic data (WES, targeted panels, WGS) covering QC, handling, processing & interpretation.
* Expertise in pathway enrichment tools and interpretation of the data to derive actionable biomarkers.
* Expertise in cancer genetics, cancer signaling and/or tumor microenvironment.
* Knowledge of statistical methods applicable to cancer biology.
* Ability to manage simultaneous projects to tight deadlines.
* R and/or Python programming and visualization expertise.
* Skilled in effective communication of sophisticated data to a non-expert.

Desirable requirements:

* Publication record in either cancer genomics/proteomics, bulk or single-cell transcriptomic applied to cancer.
* Expertise in the development of novel statistical approaches for the analysis of biological data.
* Experience with various NGS platforms and associated analytic processes (Thermo Fisher Ion Torrent, Oxford Nanopore, PacBio, etc.)
* Experience with BD Rhapsody and 10X Genomics platform analysis
* Awareness of machine learning, graph modelling, artificial-intelligence, Bayesian analytics or other non-traditional approaches to model biological data
* Ability to work effectively across multidisciplinary science teams.
* Experience contributing to the research community through publications, conferences and coding expertise.

About Our Gaithersburg Oncology Hub

The Gaithersburg site ( employs more than 3,500 experts in our field and is only a short drive from Washington, DC. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg campus offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria, game rooms, community garden and much more.

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, groundbreaking cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what's next-

Are you already envisioning yourself joining our team? Good! We can't wait to hear from you!

If you're curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.

Closing Date: June 15, 2023

Competitive remuneration and benefits apply

We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Start date: ASAP

Skills: Associate Director, Translational Medicine, Genomics Computational Biology, Gaithersburg, Oncology Research and Development

Salary: Negotiable

This employer is a corporate member of myGwork - LGBTQ+ professionals, the business community for LGBTQ+ professionals, students, inclusive employers & anyone who believes in workplace equality.

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