Senior Associate / Principal Associate Scientist, Molecular Biology

Senior Associate / Principal Associate Scientist, Molecular Biology at Generation Bio

Generation Bio is innovating genetic medicines to provide durable, redosable treatments for people living with rare and prevalent diseases. The company's non-viral platform incorporates a novel DNA construct called closed-ended DNA, or ceDNA; a unique cell-targeted lipid nanoparticle delivery system, or ctLNP; and a highly scalable capsid-free manufacturing process that uses its proprietary cell-free rapid enzymatic synthesis, or RES, to produce ceDNA. The platform is designed to enable multi-year durability from a single dose, to deliver large genetic payloads, including multiple genes, to specific tissues, and to allow titration and redosing to adjust or extend expression levels in each patient. RES has the potential to expand Generation Bio's manufacturing scale to hundreds of millions of doses to support its mission to extend the reach of genetic medicine to more people, living with more diseases, around the world.

We are a thriving, collaborative, creative community of 165 people with diverse talents, beliefs, and experiences headquartered in Cambridge, Massachusetts.

Generation Bio seeks an energetic, versatile, and highly motivated Associate Scientist to join our Molecular Biology team, within our Platform Research group. The successful candidate will support development of our novel ceDNA gene therapy platform as well as assist construct optimization for pre-clinical programs. This is a lab-based position that requires proficiency in state-of-the-art molecular & synthetic biology techniques as well as an ability to work well within cross-functional teams.

RESPONSIBILITIES:

• Optimize construct design and performance of ceDNA gene therapy platform
• Develop and execute analytical methods for the evaluation of novel constructs
• Assess construct performance and molecular attributes using mammalian cell culture
• Utilize modern synthetic biology approaches to construct DNA vectors and libraries
• Participate and present data in in cross-functional working groups
• Analyze, interpret, and report data and study summaries in the form of written and oral reports

QUALIFICATIONS:

• BS in Biology, Biochemistry, Molecular Biology, or related field with a minimum of 2 years of experience or a MS
• Minimum 2 years of relevant laboratory experience
• In-depth experience with molecular biology techniques (e.g. Homology-based Cloning, restriction-ligation methods, NGS methods, qRT-PCR, PCR, Western blot)
• Excellent organizational skills and detail-oriented focus
• Experience with NGS method design, development, and execution is highly desired.
• Experience with mammalian cell culture is highly desired.
• Experience building and screening high dimensional libraries is a plus
• Strong communication and interpersonal skills
• Willingness to learn, propose, and improve new techniques

POSITION: Full-Time, Non-Exempt

EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race (to include traits historically associated with race including, but not limited to, hair texture, hair type, hair length, and protective hairstyles such as braids, locks, twists, hair coverings, and Bantu knots), color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.