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Senior/Principal Scientist, Cancer Biology Biology

Cambridge, Massachusetts, US
Closing date
May 28, 2023

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Academic / Research
Conservation science
Salary Type
Employment Type
Full time
Why join us?

FogPharma® is pioneering the discovery, development, and commercialization of HeliconTM peptides, an exciting new drug modality that uniquely combines the cell-permeability of traditional small molecule drugs with the specificity, broad target accessibility and discovery speed of monoclonal antibody drugs. Our patented Heliconpeptide technology allows us to modulate the activity of well-known intracellular disease drivers that have thus far evaded small molecule and biologic therapies.

FogPharma's lead program targets β-Catenin, a cancer driver in the WNT pathway. Inhibition of β-Catenin has the potential to benefit more than one-fifth of all cancer patients, and is just one of many opportunities for Fog's lead-discovery platform to change future medicines, therapies and lives. We recently selected a lead development candidate and plan to initiate clinical development early next year.

What's the opportunity?

We are seeking a highly motivated Senior/Principal Scientist with significant experience in cell and molecular biology to join the biology team. You will work with a cross-functional team to develop and execute strategies to help us understand Helicon's mechanism of action and identify patient stratification biomarkers for clinical trials.
  • Independently design, develop and perform relevant assays and biological experiments to drive optimization of our proprietary Helicon peptides
  • Develop and execute on strategies to elucidate the mechanism of action and identify preclinical biomarkers for our lead Helicons
  • Accurately record, analyze, and present data to team and company leadership
  • Coordinate with external collaborators and CRO's to support our research goals
  • Efficiently communicate data and plans to the broader biology and company teams

What you'll need to be successful:
  • Ph.D. and 5-8+ years of industry experience in cancer biology
  • Hands-on experience with cell-based assay development, high throughput screening, CRISPR and/or RNAi for target validation
  • Experience in drug discovery, hit-to-lead process and matrixed team work
  • Proficiency in a broad range of molecular and cellular techniques including: target engagement NanoBRET and HiBiT assays, western blotting, qPCR, transfection, immunofluorescence, flow cytometry, cell-based functional assays
  • Experience with in vivo models and/or sample analysis is desirable but not required
  • Experience training and managing junior scientists is desirable but not required
  • Experience in managing relationships with collaborators and/or CROs
  • Innovative, creative, inquisitive, motivated researcher with strong problem-solving skills
  • Excellent written and oral communication skills
  • Able to work on-site and attend in-person meetings (Fog employees are required to be fully vaccinated to attend in-person work-related activities. Reasonable Accommodations will be made for individuals with a sincerely held religious belief or disability who are not vaccinated)

As an equal opportunity employer, Fog values diversity and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive | Cambridge, MA 02140 |

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