Senior/Principal Research Associate, Biology

Cambridge, Massachusetts, US
Closing date
May 31, 2023

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Academic / Research, Consultancy/Private Sector
Conservation science
Salary Type
Employment Type
Full time
Senior/Principal Research Associate, Biology at Flare Therapeutics

Flare Therapeutics is a biotechnology company pioneering a new therapeutic space with a novel approach to decipher the biology of transcription factors to develop small molecule medicines. Based on insights from the seminal work of its scientific founders, Flare's team has uncovered ‘switch sites,' druggable regions that are key targets for transcription factor regulation, to address mutations that cause disease. Flare's drug discovery efforts to target switch sites has rapidly advanced, resulting in an emerging pipeline of research programs that address well-validated genetically-defined transcription factors, initially focused on precision oncology.

We are a collective of brilliant fires, trailblazing a path to conquer transcription factors and create cutting-edge medicines for patients. We embrace diversity in all its forms, experiences, and viewpoints. We are inspired by the unknown and willing to take risks. We are passionate about the science we pursue and compassionate about the patients it stands to benefit. And we respect, value, and believe in each other.
In this role you will…
  • Support cell and molecular biology activities across Flare's pipeline projects
  • Contribute to experimental design and execution of efforts to understand the effects of perturbation of transcription factors and to validate novel targets for further drug discovery investigation
  • Develop and validate assays to drive drug discovery campaigns
  • Collaborate with chemistry and biochemistry colleagues to understand the mechanism of action of small molecule modulators of transcription factors to improve compound efficacy for H2L and LO advancement
  • Present data and research plans to the teams to inform data-driven decisions
About you…
  • You have a BS or MS in molecular or cellular biology
  • You have at least 3-4 years of experience in biotech/pharma
  • You have experience with cell assay development, drug discovery screening and mechanistic studies
  • You are experienced in cell engineering (shRNA, CRISPR knockin/knockout, generation of stable lines, viral transduction, etc.)
  • You have worked in oncology and/or transcriptional regulation
  • You may have experience in processing clinical samples for qPCR analysis
  • You have an aptitude to work with drug discovery databases
  • You consider yourself to be a self-starter with a great ability to prioritize and balance multiple tasks, meet multiple deadlines, and thrive in a dynamically changing and fast-paced environment
  • You have strong communication skills, both written and verbal, including presenting data to the internal company meetings
  • You have a strong passion for science and are driven by making a meaningful contribution for patients
Flare is proud to foster a diverse, equitable and inclusive company culture that embraces all people that are essential to who we are, what we do and what we believe. Flare Therapeutics is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.
TO ALL AGENCIES:Please, no phone calls or emails to any employee of Flare about our openings. All resumes submitted by search firms/employment agencies to any employee at Flare via email, the internet or in any form and/or method will be deemed the sole property of Flare, unless such search firms/employment agencies were engaged by Flare for this position and a valid agreement with Flare is in place. In the event a candidate who was submitted outside of the Flare agency engagement process is hired, no fee or payment of any kind will be paid.

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