Postdoctoral Researcher - microRNA Cardiovascular Biology

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Postdoctoral Researcher - microRNA Cardiovascular Biology Description
Ionis Pharmaceuticals, Inc., is headquartered in Carlsbad, California, with offices in Boston, Massachusetts, and Dublin, Ireland. For more than 30 years, Ionis has been the leader in RNA-targeted therapy, pioneering new markets and changing standards of care with our novel antisense technology. Ionis currently has three marketed medicines and a premier late-stage pipeline highlighted by industry-leading cardiovascular and neurological franchises. Our scientific innovation began and continues with the knowledge that sick people depend on us, which fuels our vision of becoming a leading, fully integrated biotechnology company.

As the first company to fully harness the power of RNA technology for human therapeutics, Ionis' platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. We are building upon our innovative research and drug development excellence to provide greater value to patients, and we are well positioned financially to deliver on our strategic goals.

Ionis is a challenging, motivating and rewarding environment designed to foster innovation and scientific excellence. Our success is a direct result of our outstanding employees. We are interested in bringing together a diverse group of individuals with different skill sets and perspectives into this creative environment to be part of a productive and inclusive team. While acknowledging people are actively engaged in hybrid/remote work, we continue to invest time, money, and energy into making our workplace locations a place where our culture and employees can thrive. We believe engaging on a day-to-day basis, in person, builds solid and lasting relationships, and contributes positively to our culture and innovation. From the heart of our stunning Carlsbad campus, we aim to provide a central connection point for all our employees. These facilities give us the opportunity to connect cross-functionally, collaborate and to build on the success of our business as we continue to grow. Join us and experience our unique culture while you develop and expand your career.

Postdoctoral Researcher - microRNA Cardiovascular Biology

SUMMARY:

We are seeking an enthusiastic postdoctoral scientist with expertise in microRNA (miRNA) biology to join the CardioRenal Drug Discovery group, a multi-disciplinary team of energetic researchers. The successful candidate will work on the exploratory project of utilizing oligonucleotides to modulate miR-mediated target expression. He/She will work independently to conceptualize, design and execute experiments using human iPSC-CMs and rodent models. Background in RNA biology and molecular biology are essential for the position. Experience with iPSC-CMs is a plus.

PRIMARY RESPONSIBILITIES:

• Design, execute and troubleshoot experiments relevant to the postdoctoral project
• Generate in vitro models using iPSC-CMs or rodent primary cardiomyocytes
• Analyze and present results at both internal and external scientific meetings
• Prepare manuscript for publication

REQUIREMENTS:

• Ph.D. with 0-3 years of postgraduate experience in molecular biology or related fields
• Strong laboratory skills in standard assays such as RNA and protein isolation, RT-qPCR, ELISA, Western Blotting
• Hands-on experience with miRNA research modalities (isolation, quantification, immunoprecipitation, affinity assay, luciferase reporter assay, etc)
• Experience with gene editing (CRISPR) or cardiomyocyte culture (primary and/or iPSC-CMs) is a plus
• Proficiency in rodent handling, dosing and necropsy is a plus but not required
• Excellent written and verbal communication skills

Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits

Full Benefits Link: https://www.ionispharma.com/careers/working-at-ionis/#:~:text=our%20employee%20spotlight-,Benefits,-Employees%20are%20rewarded

The pay scale for this position is $54K to $65K

NO PHONE CALLS PLEASE. PRINCIPALS ONLY.

Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.