Associate Director/ Director, Computational Biology

Associate Director/ Director, Computational Biology at Flare Therapeutics

Flare Therapeutics is a biotechnology company pioneering a new therapeutic space with a novel approach to decipher the biology of transcription factors to develop small molecule medicines. Based on insights from the seminal work of its scientific founders, Flare's team has uncovered ‘switch sites,' druggable regions that are key targets for transcription factor regulation, to address mutations that cause disease. Flare's drug discovery efforts to target switch sites has rapidly advanced, resulting in an emerging pipeline of research programs that address well-validated genetically-defined transcription factors, initially focused on precision oncology with future potential in neurology, rare genetic disorders, immunology and inflammation.

We are a collective of brilliant fires, trailblazing a path to conquer transcription factors and create cutting-edge medicines for patients. We embrace diversity in all its forms, experiences, and viewpoints. We are inspired by the unknown and willing to take risks. We are passionate about the science we pursue and compassionate about the patients it stands to benefit. And we respect, value, and believe in each other.

Join an agile multidisciplinary team meeting the future precision medicine-driven drug discovery today. Be part of a team at the intersection of pre-clinical, translational studies & early clinical program advancement leveraging molecular real-world data and applying next-gen disruptive technology to bridge the bench to patient paradigm. The [associate] director will play a critical role in setting the strategy for the nascent group and lead data analysis initiatives.
In this role you will...

• Identify and lead specific strategic initiatives in target and biomarker identification, and validation
• Use existing public or licensed datasets to define target patient populations and propose stratification biomarkers
• Apply cancer genetics and transcriptomics data to identify and/or prioritize new candidate targets
• Spearhead data analysis including supervision of external teams (COR, consultants) to deliver across the portfolio
• Own the design of experiments and provide robust analysis plans
• Oversee or perform the actual QC and analysis
• Communicate results and discuss interpretation with larger program teams
• Integrate multiple datasets to support drug development pipeline
• Establish and maintain best data practices for Flare
• Provide input and guidance on technology enablement
• Drive the adoption and implementation of innovative algorithms
• Ensure the reproducibility of results
• Help expand and enhance a novel target identification mass spectrometry-based platform

About you...

• You have a PhD in computational biology, genetics or molecular biology.
• You have a minimum of 5 years' industry experience with 3 years translational research experience a plus.
• You have a deep understanding of bioinformatics, clinical informatics, and fluency in integrating and leveraging orthogonal diverse data types to support hypothesis and mechanistic underpinnings of disease and drug action.
• You have experience with NGS data, understanding of mass spec data is desirable.
• You may even have experience in an oncology setting.
• You might also have exposure to evolutionary biology.
• You have demonstrated proficiency with git, Python and / or R, and other modern DevOps practices.
• You may also have experience with AWS.
• You may have experience with HPC and container orchestration.
• You have the ability to manage and develop people. .
• You may have exposure to systems biology approaches and methodologies.
• You have a demonstrated track record of complex problem solving, critical thinking and leading others to achieve novel insights.
• You have the capacity to manage ambiguity and uncertainty, within a fast growing, dynamic and risk-taking environment with resiliency, higher order multitasking skills and self-motivation.
• You have strong communication skills, both written and verbal, in particular delivering compelling scientific narratives attuned to a particular audience.
• You enjoy contributing to driving a culture of innovation.
• You love science and have a sense of humor.

Flare is proud to foster a diverse, equitable and inclusive company culture that embraces all people that are essential to who we are, what we do and what we believe. Flare Therapeutics is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.
TO ALL AGENCIES:Please, no phone calls or emails to any employee of Flare about our openings. All resumes submitted by search firms/employment agencies to any employee at Flare via email, the internet or in any form and/or method will be deemed the sole property of Flare, unless such search firms/employment agencies were engaged by Flare for this position and a valid agreement with Flare is in place. In the event a candidate who was submitted outside of the Flare agency engagement process is hired, no fee or payment of any kind will be paid.