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Principal Scientist | Chemical Biology

San Francisco, California, US
Closing date
Feb 14, 2023

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Academic / Research
Conservation science
Energy, Biology
Salary Type
Employment Type
Full time
Weatherwax Biotechnologies is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine yields molecules that co-opt existing cellular machinery to overcome exigent therapeutic challenges which have remained unapproachable to other modalities for decades.

We are seeking first-rate chemical biologists to help us pioneer this uncharted frontier of drug discovery.
Our Story
A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA approved drugs is inhibition[1], but there are many other possible perturbation types whose potential remains unrealized.

Weatherwax Biotechnologies is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).

Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[2, 3, 4], and our approach will be no different.
The Position
We are seeking an experienced chemical biologist to be a founding member and leader of our Platform Team. In this position you will work in close conjunction with our Biology Team and Chemistry Team in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.

Your responsibilities will include: leading the build-out and optimization of our in-house drug discovery platforms, designing, performing, and/or supervising both low and high-throughput screening assays, supervising mechanistic studies on lead drug molecules, developing cell-based disease models for phenotypic screening, and spearheading forays into new disease areas.
About You
High Agency. Initiative, independence, and self-accountability are some of our most valued traits.

Enthusiastic. We love people who are excited about what they are doing, and are generally attempting to build a high-energy team.

Intensity and Grit. Early-stage startups are hard. Drug discovery doubly so. We are looking for candidates who have a demonstrated ability to stick with hard problems for the long haul, with a team that has your back along the way.

Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be too.
Qualifications & Nice-To-Haves
  • PhD in Chemical Biology, Medicinal Chemistry, Biochemistry, or related field
  • 5-7+ years of industry experience
  • Deep understanding of two or more of the following drug discovery platform technologies:
  • DEL development/screening
  • HTS and fragment based screening approaches
  • Development and execution of phenotypic screens
  • Chemo-proteomic drug discovery
Experience with:
  • Biophysical small-molecule characterization techniques such as SPR
  • PPI characterization techniques
  • Target/indication selection
  • Hit finding and hit-to-lead studies
  • Pre-clinical and IND-enabling studies
  • Managing a team of exceptional scientists
Nice to have:
  • Proteomics experience: PTM analysis, TMT, top-down studies
  • Familiarity or experience with PROTACs (or related CIDs)
  • Computational drug discovery experience
  • Experience managing FTEs at a synthetic chemistry CRO
  • Prior experience on teams that have successfully advanced research to the clinic
  • Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.
  • Top tier medical, dental, and vision coverage + One Medical membership.
  • 401(k) retirement plans.
  • Education and health/fitness incentive programs.
  • Reading budget! We will buy you books

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