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(Senior) Research Associate/Associate Scientist/Scientist, Molecular and Cell Biology

South San Francisco, California, US
Closing date
Dec 9, 2022

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Academic / Research
Conservation science
Salary Type
Employment Type
Full time
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seeking talented and highly motivated scientists to join our Molecular and Cellular Biology group. This position offers an opportunity to work as part of a small, dynamic team to elucidate and model target biology through in vitro assays. The successful candidate will develop robust, target specific cell-based binding and functional assays to screen and rank therapeutic antibodies or protein therapeutics for lead selection. The focus of the position is to conduct laboratory-based experiments and in vitro screens. Attention to detail is a must along with strong skills in multi-tasking, optimizing robust assays, troubleshooting technical issues during assay development and the ability to organize, summarize and present results to technical teams.

What Your Responsibilities Are:

* Assess multiple aspects of Treg biology in vitro in response to modulation with monoclonal antibodies and protein therapeutics using cell-based screening
* Develop cell-based assays to answer biological questions, e.g.


* Cell-Based Binding
* Ca2+ Flux
* Reporter Assays
* ADCC (Annexin V/CFSE)
* Phospho-flow/signaling
* Drive lead selection of therapeutic biologics through delivery of high quality, decision-enabling datasets
* Collaborate with other departments (e.g. Biotherapeutics, Discovery) in the creation of screening strategies, program execution, and lead selection
* Be rigorous and thoughtfully critical in design and execution of protocols, documentation, and technical reports
* Clearly communicate work to team members, collaborators and other stakeholders

Who You Are:

* BS in immunology, biology, or related discipline with 2 years industry experience for Associate Scientist level
* BS with 7+ years of experience, MS with 5+ years of experience or PhD with 1+ years of industry experience for Scientist position
* Experience with mammalian cell culture including primary immune cells, hands-on experience with multi-color flow cytometry, and intracellular cytokine staining
* Experience with serum-based or cell-based immunological assays to assess the activity of proteins is essential, e.g., (any) ELISA, multiplex analysis (Luminex, MSD), cell-based functional assays (proliferation, activation, cytokine responses), lentiviral and CRISPR-based applications, or reporter-based assay platforms
* Experience with FACSDiva, FlowJo, Prism, and Microsoft Office programs
* Experience with high throughput screening (100s of unique conditions per experiment) is a plus
* Imaging or Incucyte experience is a plus
* You are curious to learn new biology, insightful, detail-oriented, organized, collaborative, and flexible with a positive "can-do" attitude

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