Scientist I/II, Immunology/Cancer Biology

Job Description
Position Summary:

Affini-T Therapeutics is an emerging biotechnology company focused on building a "best-in-class" TCR therapy platform. Our innovative method of discovering high affinity TCRs specific to oncogenic mutations enables development of solid tumor therapies. Through the application of gene editing and synthetic biology, we will focus on enhancing T-cell fitness to overcome the immunosuppressive tumor microenvironment.

Affini-T Therapeutics is announcing a Scientist, Synthetic Biology, opportunity at their Boston, MA Headquarters.

• We are looking for a biologist who will play an important role in developing our TCR-T cell therapy platforms as well as applying innovative research biology approaches to develop next-gen cell therapy products. The individual should be able to independently plan and execute TCR-T cell production, assay and model development, and characterization studies for novel cell enhancements and TCRs specific for oncogenic driver mutations. Requirements also include preparing study protocols, reports, technology transfer documentation, and regulatory documents for clinical trials. The candidate is expected tocollaborate across the entire cell therapy discovery spectrum, contributing to target identification and validation, TCR engineering, gene editing, and novel armoring strategies to improve the fitness of T cells or modulate the immunosuppressive signals from the tumor microenvironment. Previous experience in Immuno-Oncology and understanding of the pharmaceutical industry within the cell therapy field is preferred. The successful candidate will be a great team player, hard worker, and have outstanding communication skills

Essential Duties and Responsibilities:

The major tasks for this position are as follows:

• Design, execute and critically analyze in vitro/ex vivo studies to develop and characterize TCR-engineered T cell therapy products
• Able to independently manage her/his workload, design and perform bench activities independently or with minimal supervision, able to drive novel research strategies
• Able to manage project timelines and perform time sensitive experiments to drive discovery programs accordingly with departmental, functional and external stakeholders
• Apply recent developments in cell therapy-related novel technologies to design and create the next generation cell therapy platforms
• Plans and implements resolutions to technical problems/issues
• Serves as a technical resource for junior staff and leverages expertise in laboratory technology as a functional resource/trainer
• Contributes significantly and independently to multiple projects executed in parallel
• Share biology lab operation, equipment and cell bank maintenance responsibilities
• Accountable for the development of culture and capabilities within the Synthetic Biology team

Desired and Required Qualifications:

Education and Experience:

• Ph.D. in cell biology, Oncology or Immunology (Immuno-oncology background is highly preferred) with 0+ years relevant industry experience; or B.S./ M.S. in biology with 7+ years relevant industry experience
• Expertise in mouse and human T cell isolation, culture, engineering and complex cell-based assays for functional characterization
• Expertise in flow cytometry including designing and optimizing multi-parameter flow cytometry panels

The successful candidate will have the following attributes

• Ability to work independently, generate, analyze and interpret data with scientific rigor and open mind
• Able to troubleshoot critical issues or problems, and determine causes and possible solutions
• Subject matter expertise and knowledge of applicable lab equipment and operations
• Exercises good time management and prioritization skills and can successfully manage multiple tasks simultaneously
• Ability to work well in a highly cross-functional team environment
• Is very comfortable working with his/her team members in the laboratory
• Is highly creative, collaborative, and thrives in a dynamic matrix environment
• Proven skills as an effective team player who can engender credibility and confidence within and outside the company
• Excellent oral and written communication skills, including writing, reviewing and editing scientific documents and presenting to a range of stakeholders, as well as scientific posters or lectures at professional conferences or events
• Fit with Affini-T core values, mission and vision, including the highest personal values and ethical standards, creating a culture that fosters innovation
• Possess the right attitude (agile, curious, positive, open-minded, "can-do" mindset), and have the ability and strong desire to "make things happen"

Physical Requirements

• Sit for extended periods of time (2 or more hours)
• Occasionally lift or carry up to 20 kg

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