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Research Associate - Protein Biochemistry/Microbiology/Molecular Biology

ContraFect Corp
Yonkers, New York, US
Closing date
Dec 9, 2022

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Academic / Research
Conservation science
Salary Type
Employment Type
Full time
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ContraFect Corporation is a clinical-stage biotechnology company focused on the discovery and development of protein therapeutics and antibody products for life-threatening, drug-resistant infectious diseases. We are committed to innovative drug development, leading the way with novel technologies to create new therapies that address the high unmet medical needs of patients suffering from serious infections for which there are limited available treatment options. The company is located in Westchester County, near New York City.

An opportunity is available to grow with us in an environment that is both challenging and energetic.
ContraFect is seeking self-motivated and collaborative individuals to join our team and to contribute their talent and expertise. We are looking for positive individuals who will add to our committed and dedicated employee base and contribute to the development of novel therapeutic agents which have the potential to change the therapeutic landscape for treating serious infections.

It is an exciting time in our Company's history. Exebacase (CF-301), our lead compound, is the first and only bacteriophage-derived lysin (cell wall hydrolase) to enter Phase 3 clinical trials in the US and recently reported positive results from a Phase 2 Proof of Concept clinical trial for the treatment of S. aureus bacteremia including endocarditis. Exebacase, which targets Staphylococcus aureus , including MRSA, is the first of a new class of direct lytic agents for the treatment of serious bacterial infections. Beyond exebacase, we have an exciting pre-clinical and discovery pipeline of lysins and other direct lytic agents targeting a range of antibiotic resistant Gram-positive and Gram-negative bacteria. Our primary focus in on developing treatments for bacteria designated by CDC and the WHO as urgent or serious threats of critical or high priority.

We are using ContraFect's technical expertise to develop biotherapeutic products for infectious diseases that have high unmet medical needs, particularly products to treat critically ill, hospitalized patients with serious and potentially life threatening infections.

Position Summary: The position will play an integral role in the day-to-day operation of the ContraFect Research Laboratory and conduct of studies in the field of protein-based therapeutics to treat serious bacterial infection.

Specific responsibilities:

* Under the direction of senior personnel, perform research activities in a diverse microbiology laboratory with a wide research base that will focus on the following areas:
* Induction, expression, purification, and characterization of recombinant protein targets and protein candidate therapeutics
* Molecular cloning and plasmid production in E. coli , creative protein design and optimization, DNA library preparation and screening, and cell-based activity assays
* Develop and use antimicrobial susceptibility testing (AST) methodologies (including MIC and anti-biofilm assays, synergy studies, resistance assays) to profile in vitro microbiologic characteristics of target antimicrobials
* Mechanism of action studies
* Bioassays to support preclinical studies (e.g. ELISAs, etc.)
* Handling, maintenance and study of BSL1 and BSL2 microorganisms
* Participate in the planning, conduct and reporting of experiments performed in the lab
* Maintain clear, legible and detailed laboratory notebooks and computer files
* Maintain a clean work environment and participate in general lab maintenance
* Provide assistance in analyzing data, applying problem-solving skills, and resolving technical issues
* Writing and preparing study reports, conference abstracts and presentations, standard operating procedures, and manuscripts for publication

Position Qualifications

* A Bachelors' degree, Master's degree or Ph.D. in Biochemistry, Molecular Biology, Microbiology or related field with 3+ years of hands on research experience in pharmaceutical, biotechnology or academic settings
* Scientific writing skills
* Prior experience in a drug-discovery setting in company is a plus
* Experience with methods defined by the Clinical and Laboratory Standards Institute (CLSI) is a plus
* Prior work with standard scientific equipment as described in relevant procedures; UV spectrophotometer, balances, chromatography columns, SDS-PAGE, autoclaves, pH meter, refrigerators, freezers, biohazard safety cabinets
* Meticulous organization and record keeping skills
* Attention to detail
* Ability to work collaboratively with others as a member of the team to ensure that projects are handled smoothly and cooperatively to enhance success of project and maintain strong relationships within all parts of company

ContraFect Corporation is an equal opportunity employer. We recognize the power and importance of a diverse employee population and strongly encourage applicants with various experiences and backgrounds. All qualified applicants will be considered for employment and we will not discriminate against applicants for employment on the basis of race; color; religion; genetic information; national origin; sex; pregnancy, childbirth, or related medical conditions; familial status; age; disability; citizenship status; military or veteran status; or any other protected class under federal, state, or local law.
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