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Senior Research Associate / Scientist, Early Discovery Molecular Biology

Monte Rosa Therapeutics
South Boston, Massachusetts, US
Closing date
Dec 8, 2022

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Academic / Research
Conservation science
Genetics, Biology
Salary Type
Employment Type
Full time
Senior Research Associate / Scientist, Early Discovery Molecular Biology
Location : Boston, MA

Monte Rosa Therapeutics is seeking an energetic and self-motivated (Senior) Research Associate to join our innovative team working towards discovery of unique molecular glue degraders for the treatment of targeted patient populations in indications including auto-inflammatory disease, hematology and oncology. This is a lab-based position that offers the opportunity to impact projects as they progress from target validation and hit-finding, through to lead optimization and pre-IND studies.


* Validate targets and/or target rationale
* Aid with early discovery biology on chosen targets and/or strategy
* Help guide, design, and execute the validation of hits from high-throughput screens using cellular assays
* Develop and independently perform an array of molecular biology assays (e.g. viability assays, western blotting, qPCR, and/or NanoBRET) to define mechanism of action of molecular glue degraders


* Bachelors or Masters in cell/molecular biology, cancer biology, or genetics with 5+ years' experience in biopharma industry
* Experienced cell and molecular biologist with hands-on experience in oncology small molecule drug discovery
* Experience with a variety of molecular biology methods and assays such as immunoblotting, CRISPr/RNAi, transfection and transduction, ELISA/AlphaLisa, and NanoBRET
* Experience preparing drug dilutions and performing drug viability/cytotoxicity experiments
* Experience in early drug discovery
* Protein degradation experience is a plus

Interested candidates should forward a resume, publication list and cover letter to . Or apply on line

Monte Rosa's rational approach to targeting disease-causing proteins for degradation will deliver pioneering therapies for cancer and inflammatory and other diseases. Currently, there exist thousands of proteins targets that remain ‘undruggable' by conventional means. Delivering a new generation of treatments to patients requires a conceptual change. Monte Rosa recognizes this urgent and unmet need and is missioned to develop innovative protein degraders as a solution. Combining deep knowledge, insight and leading-edge science, our integrated engine is built for that purpose.

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