Scientist Early Target Biology

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Research Scientist, Cambridge, MA

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The Research Scientist will join the Oncology Early Target Biology group at Bristol-Myers Squibb in Cambridge, MA to aide in the advancement of early-stage therapeutic targets. The position will utilize genome engineering, mechanistic biology, cell-based assays, and other cutting-edge technologies to validate tumor intrinsic targets and support the drug discovery pipeline. The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment and aid the advancement of the next wave of targets into preclinical drug development. The candidate is expected to effectively collaborate with colleagues across discovery oncology including the exploratory pharmacology, drug discovery and translational research groups. The position requires the ability to design, iterate, and lead several key project initiatives and demonstrate critical thinking to challenge self and others. The successful candidate will demonstrate clear and professional verbal and written communication skills and will be capable of communicating their results across multidisciplinary teams.

Qualifications, Experience, & Key Responsibilities

• A B.S. with a minimum of 7 years, a M.S. with a minimum of 5 years, or a PhD with a minimum of 3 years of combined academic and industry experience with strong scientific knowledge and research experience in cancer biology/cellular and molecular biology is required.
• Hands on experience with a wide range of cellular and molecular biology techniques, including 2D and 3D tissue culture, flow cytometry, western blotting, Immunoprecipitation, development of reporter assays, MSD, ELISA, use of genetic perturbation techniques (eg shRNA, siRNA, CRISPR-mediated genome editing), qRT-PCR, cell proliferation assays, lentivirus generation and transduction is required.
• Experience in developing and executing forward and reverse genetic screening followed by target validation studies to elucidate mechanistic biology and oncogenic SAR is required.
• Knowledge of preclinical drug development including knowledge of designing assays and flowcharts to identify and optimize drug candidates is preferred.
• Experience in cancer genome data mining through use of desktop tools/interfaces and public databases (e.g., CBIO, TCGA, CCLE, Genepattern etc) is highly desirable.
• Proficiency in utilizing software such as Graph Pad, FlowJo, Microsoft office etc. for data analysis and figure generation is required.
• Demonstrated independence in experimental design, execution, data analysis and troubleshooting are required.
• Ability to mentor more junior scientists and colleagues on best practices in the laboratory would be highly valued.
• Attention to detail with excellent organizational and record keeping skills is a requirement.
• Excellent interpersonal skills with the ability to interact effectively with people, internally and externally is required.
• This position is located in Cambridge, MA. There will be less than 10% travel.

Why You Should Apply

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

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