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(Senior) Research Associate/Associate Scientist/Scientist, Molecular and Cell Biology

South San Francisco, California, US
Closing date
Dec 2, 2022

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Academic / Research
Conservation science
Salary Type
Employment Type
Full time
seeking talented and highly motivated scientists to join our Molecular and Cellular Biology group. This position offers an opportunity to work as part of a small, dynamic team to elucidate and model target biology through in vitro assays. The successful candidate will develop robust, target specific cell-based binding and functional assays to screen and rank therapeutic antibodies or protein therapeutics for lead selection. The focus of the position is to conduct laboratory-based experiments and in vitro screens. Attention to detail is a must along with strong skills in multi-tasking, optimizing robust assays, troubleshooting technical issues during assay development and the ability to organize, summarize and present results to technical teams.

What Your Responsibilities Are:

* Assess multiple aspects of Treg biology in vitro in response to modulation with monoclonal antibodies and protein therapeutics using cell-based screening
* Develop cell-based assays to answer biological questions, e.g.


* Cell-Based Binding
* Ca2+ Flux
* Reporter Assays
* ADCC (Annexin V/CFSE)
* Phospho-flow/signaling
* Drive lead selection of therapeutic biologics through delivery of high quality, decision-enabling datasets
* Collaborate with other departments (e.g. Biotherapeutics, Discovery) in the creation of screening strategies, program execution, and lead selection
* Be rigorous and thoughtfully critical in design and execution of protocols, documentation, and technical reports
* Clearly communicate work to team members, collaborators and other stakeholders

Who You Are:

* BS in immunology, biology, or related discipline with 2 years industry experience for Associate Scientist level
* BS with 7+ years of experience, MS with 5+ years of experience or PhD with 1+ years of industry experience for Scientist position
* Experience with mammalian cell culture including primary immune cells, hands-on experience with multi-color flow cytometry, and intracellular cytokine staining
* Experience with serum-based or cell-based immunological assays to assess the activity of proteins is essential, e.g., (any) ELISA, multiplex analysis (Luminex, MSD), cell-based functional assays (proliferation, activation, cytokine responses), lentiviral and CRISPR-based applications, or reporter-based assay platforms
* Experience with FACSDiva, FlowJo, Prism, and Microsoft Office programs
* Experience with high throughput screening (100s of unique conditions per experiment) is a plus
* Imaging or Incucyte experience is a plus
* You are curious to learn new biology, insightful, detail-oriented, organized, collaborative, and flexible with a positive "can-do" attitude


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