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Principal Scientist, Cell Biology (Oncology)

North Cambridge, Massachusetts, US
Closing date
Nov 28, 2022

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Academic / Research
Conservation science
Salary Type
Employment Type
Full time
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Principal Scientist - Cell Biology, Oncology
Cambridge, MA (onsite)

What's the opportunity?
We are seeking a highly motivated Principal Scientist with significant experience in cell and molecular biology to join the biology team. You will work with a cross-functional team to develop and execute strategies to help us understand Helicon's mechanism of action and identify patient stratification biomarkers for clinical trials.


* Independently design, develop and perform relevant assays and biological experiments to drive optimization of our proprietary Helicon peptides
* Develop and execute strategies to elucidate the mechanism of action and identify preclinical biomarkers for our lead Helicons
* Accurately record, analyze, and present data to team and company leadership
* Coordinate with external collaborators and CROs to support our research goals
* Efficiently communicate data and plans to the broader biology and company teams

What you'll need to be successful:

* Ph.D. and 8+ years of industry experience in cancer biology
* Hands-on experience with cell-based assay development, high throughput screening, CRISPR, and/or RNAi for target validation
* Experience in drug discovery, hit-to-lead process and matrixed team work
* Proficiency in a broad range of molecular and cellular techniques including target engagement NanoBRET and HiBiT assays, western blotting, qPCR, transfection, immunofluorescence, flow cytometry, cell-based functional assays
* Experience with in vivo models and/or sample analysis is desirable but not required
* Experience training and managing junior scientists is desirable but not required
* Experience in managing relationships with collaborators and/or CROs
* Innovative, creative, inquisitive, motivated researcher with strong problem-solving skills
* Excellent written and oral communication skills
* Able to work on-site and attend in-person meetings

Apply today!
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