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Director/Senior Director, Biology

DTx Pharma
San Diego County, California, US
Closing date
Nov 28, 2022

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Academic / Research
Conservation science
Salary Type
Employment Type
Full time
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Company Overview :

DTx Pharma, Inc. is a privately held biotechnology company based in San Diego, CA creating novel RNA-based therapeutics to treat the genetic drivers of disease. The company's proprietary delivery technology platform utilizes fatty acids as targeting ligands to enable the delivery of oligonucleotide therapies to tissues and cell types throughout the body. In preclinical studies, DTx has demonstrated cellular uptake and broad activity of oligonucleotides in the retina, muscle, heart, neurons, T cells, and other specialized cell types. To advance the FALCON platform toward and into clinical development, DTx has raised more than $100M in combined investment from several of the world's leading healthcare investors including RA Capital Management and Access Biotechnology, pharmaceutical companies such as Eli Lilly and Company, the National Institute of Health (NIH), and research foundations such as the CMT Research Foundation (CMTRF). To learn more about DTx Pharma, please visit and follow DTx on LinkedIn and Twitter @DTxPharma.

DTx Pharma is seeking a highly motivated, results-oriented Director or Senior Director to join our biology team. The ideal candidate has extensive experience in drug discovery and development, leading projects in a matrix environment and managing direct reports. The candidate must be experienced at leading programs from discovery into IND-enabling studies, designing pharmacology and pharmacodynamic studies, assessing potential new indications, and determining mechanism of action of novel compounds. The successful candidate will be a critical player in our efforts to utilize our technology for RNA medicines to improve the lives of patients.

Essential Duties and Responsibilities:

* Driving preclinical drug discovery programs in a matrix environment to develop strong support for progressing programs into clinical stage by designing in vitro and in vivo pharmacology, efficacy, and mechanism of action studies
* Managing direct reports to effectively progress preclinical programs
* Represent research team on Development teams
* Contribute to drafting reports, investigator brochures, patents, and publications
* Assess new target and indication opportunities
* Interact effectively with other departments including chemistry and DMPK to manage programs
* Manage external collaborations including with CROs and academic investigators


* PhD or MD with at least 15 years of experience in drug discovery and development with a proven track record of leading programs to IND in a biotechnology or pharmaceutical company
* Deep knowledge of biology in neuromuscular, neurology and/or CNS-related disease areas as demonstrated by relevant publications
* Experience in managing direct reports including PhD reports
* Strong background in relevant technologies such as qPCR, gene expression analysis and RNAseq
* Background in RNA therapeutics is not required, but considered a plus
* Ability to effectively communicate and lead in collaborative fast-paced team environment

DTx Pharma is an Equal Opportunity Employer. We evaluate qualified applicants without regard to race, color, national origin, religion, sex, disability, veteran status, and other statuses protected by law. We offer all candidates the opportunity to challenge their abilities in a dynamic work environment and your efforts will be recognized through a competitive compensation program. We thank all candidates; however, only those selected for an interview will be contacted.
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