Principal Scientist - Translational Biology

COMPANY DESCRIPTION:

Every Exelixis employee is united in an ambitious cause: to launch innovative medicines that give patients, and their families hope for the future. In this pursuit, we know our employees are our most valuable asset. After operating in the challenging biotech sector for 25 years, we have a proven track record of resiliency in the face of adversity. The success of our lead product has provided a solid commercial foundation allowing us to reinvigorate our research efforts and grow our team in areas such as Drug Discovery, Clinical Development and Commercial.

As we expand our global partnerships and further reinvest in R&D to help us discover the next breakthrough for difficult-to-treat cancers, we're seeking to add talented, dedicated employees to power our mission.

Cancer is our cause. Make it yours, too.

SUMMARY/JOB PURPOSE:

We are seeking an innovative scientist to drive Exelixis' Translational Biology in Oncology Discovery. Under the collaborative environment, the successful candidate will apply cellular and molecular biology, biomarker identification and validation, assay development and execution et al to identify and validate pharmacodynamic and predictive biomarkers, to establish PK/PD/efficacy relationship, to elucidate MoA and combination strategies to guide the discovery of life-changing cancer therapies.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

• Represent translational biology team in cross-functional meetings and generate translational data to drive the emerging leading pipelines forward
• Develop translational strategies and deliver translational data by collaborating with multiple functional teams including tumor biologists, in vitro and in vivo pharmacology, bioinformatics, DMPK, and chemists et al for elucidating PK/PD/efficacy relationship, indication and patient selection, and combination strategies et al
• Design, establish, and maintain translational biology lab in functional status to allow translational experiments for data-driven drug-discovery
• Communicate findings at internal and external meetings

SUPERVISORY RESPONSIBILITIES:

• Directing work (direct reports depending on the previous working and management experience)

EDUCATION/EXPERIENCE/KNOWLEDGE & SKILLS:

Education:

·Bachelor's degree in cellular and molecular biology, cancer biology, immunology, genetics, or similar field and 11 years of experience; or

·Master's degree in cellular and molecular biology, cancer biology, immunology, genetics, or similar field and 9 years of experience; or

·PhD degree in cellular and molecular biology, cancer biology, immunology, genetics, or similar field and 5 years of experience; or

·Equivalent combination of education and experience

Experience:

• Successful track record in advancing multi-disciplinary drug-discovery projects
• Experience in translational biology in either preclinical or clinical setting, for example, identification and validation of predictive biomarkers to guide the clinical development of therapeutics
• Extensive expertise in biological experimental techniques including RT-qPCR, western blot, ELISA, IHC/ISH/IF, cell-based assays, FACs analysis, RNA-seq et al
• Experience in cell culture, stable cell line establishment, gene manipulation including gain-of-function or loss-of-function studies
• Strong capability with record keeping, data summarizing, and interpreting

KNOWLEDGE/SKILLS/ABILITIES:

• Knowledge in solid tumor biology, cancer signaling pathways, oncogenes or tumor suppressor genes in cancer
• Strong scientific and technological knowledge by keeping up with the updated translational approaches and literature
• Excellent problem-solving, collaboration, and interpersonal skills
• Strong oral and written communication and good organizational abilities
• Strong scientific expertise demonstrated by track record of publications

WORKING CONDITIONS:

·Environment: working in both wet lab and office environment

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DISCLAIMER

The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.

We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.

If you like wild growth and working with happy, enthusiastic over-achievers, you'll enjoy your career with us!

DISCLAIMER
The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.

We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.