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Director, Chemical Biology

Exo Therapeutics, Inc.
MA, Massachusetts, US
Closing date
Nov 29, 2022

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Academic / Research, Consultancy/Private Sector
Conservation science
Salary Type
Employment Type
Full time
Exo Therapeuticsis a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets.

Exo Therapeutics ( ) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company's ExoSight™platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company's team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.


Exo Therapeutics seeks a highly motivated Director-level candidate with a strong background in chemical biology to serve as a key part of Exo's efforts to build an engine that can identify and validate exosites across the human proteome. You will work at a critical juncture of disciplines with opportunities to contribute to the structural evaluation of protein constructs, the design of tool and probe molecules, and the establishment of new biochemical assays for mechanism of action studies. You will then use that knowledge to work with a multidisciplinary team to build drug discovery programs that will deliver on the extraordinary promise of exosite-targeted therapeutics.

As the Director of Chemical Biology, you will help shape the company's early target discovery strategy and guide the development of a team to assist you in this role. We are keen to identify a proactive self-starter of outstanding potential with the technical skills to set a vision of success and the collaboration skills to lead a team there, both with Exo staff as well as with external collaborators. As part of a rapidly growing, early-stage company you will also participate in the build-out and maintenance of our growing laboratory space.


• Help us find exosites: evaluate target proteins across the human proteome, propose research to validate novel exosites, and deliver tools and probes to enable therapeutic programs towards those sites
• Work with the head of platform technology to identify and enable tool sets that build Exo's research foundation and establish a long-term direction for novel target research
• Serve as a key leader in a discovery team tasked with delivering compelling drug discovery programs
• Understand the scientific challenges facing Exo and build, develop, and lead a group that can support the company's growing needs
• Contribute your expertise and perspective to the strategic direction of the company's early target ID platform

Required Qualifications

• Ph.D. in chemical biology, biochemistry, or related discipline and 6+ years of industrial experience or BS/MS candidates with 11+ years of experience
• Proficiency in target discovery and validation sciences
• Excellent communicator with a collaborative mindset who can represent the Chemical Biology function to internal and external stakeholders
• The ability to motivate and develop a team to its highest potential with experience in the leadership of scientific programs
• An strategic thinker who is excited to be the primary architect of chemical biology at Exo
• Skills in adjacent fields is a plus for this multidisciplinary role including structural biology, computational chemistry, biochemistry, or medicinal chemistry

All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

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