Vigil Neuroscience is the world's first microglia-focused therapeutics company. Our purpose is clear: to treat rare and common neurodegenerative diseases by restoring the vigilance of the microglia, the sentinel cells of the brain's immune system. We are utilizing the tools of modern neuroscience drug development across multiple therapeutic modalities to rapidly deliver precision-based therapies to improve the lives of patients and their families.
We are looking for a skilled and highly motivated Senior Scientist
to join our Discovery Biology team. Reporting to the Director of Translational Sciences and External Innovation, the successful candidate will have extensive experience in immunology, cell biology, molecular biology and/or biochemistry, and will be responsible for the execution of assays for novel therapeutics targeting neuroinflammation, with a primary focus on microglia. The ideal candidate is highly organized, independent, technically creative, and excited to excel in a lab-focused, scientific role. Key Responsibilities:
- Design and execution of in vitro biochemical, signaling, and functional assays using human iPSC-derived microglia and human cell lines across multiple projects.
- Culture and maintenance of cell lines and microglia (rodent and human iPSC-derived) to support innovative drug discovery programs.
- Contribute to cross-functional internal projects teams by presenting data and ideas to key stakeholders.
- Support of external publications and conference presentations.
- Keeping up-to-date and well-organized records of experiments in an electronic notebook.
- Ideally deep and broad experience in neuroinflammation or immunology.
- Experience in culture of primary mammalian cells and transformed cell lines.
- Experience with human iPSC-derived microglia or other myeloid cells is a plus.
- Experience in optimization and execution of cell-based assays, as well as functional immune cell assays (AlphaLISA, HTRF, flow cytometry).
- Experience with western blotting, ELISA, qPCR, MSD.
- Extensive knowledge of cell biology, molecular biology, and biochemistry techniques.
- Research experience with receptor biology and cell signaling pathways is a plus.
- Familiarity with current research in glial biology, immunology, neuroimmunology and/or neuroinflammation.
- Ability to multitask and work independently.
- Excellent and oral communication skills.
- To be considered for this role, you must have a BS, MS or PhD in Biology or a related field, with typically 10+ (BS), 8+ (MS) years of relevant industry experience, or 2+ (PhD) years of postdoc experience either in industry or academia with superb technical training.
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