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Principal Scientist, Computational Biology

Cambridge, Massachusetts, US
Closing date
Oct 11, 2022

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Academic / Research
Informatics / GIS
Genetics, Biology
Salary Type
Employment Type
Full time
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Principal Scientist, Computational BiologyCambridge, MA

The Precision Medicine & Computation Biology (PMCB) research function at Sanofi is looking for a highly motivated computational biologist scientist to join recently formed genetics & genomics lab in PMCB Computational Biology Cluster. The post-holder will closely collaborate within a multi-disciplinary group of talented scientists and will be responsible to perform multiomics analysis and systems biology modeling for the discovery of novel therapeutic targets, pathways, and validation of mechanisms of action for Immunology, Oncology, and Rare and Neurological Diseases. He/She will lead the development and implementation of state-of-the-art computational methods for extracting knowledge from large scale transcriptomics databases. The candidate will work in an exciting, interdisciplinary environment, overlapping the different stages of the discovery pipeline, by interacting with multiple internal and external organizations. A close interaction and synergy with all PMCB in-silico and experimental clusters and therapeutic area functions will be expected.

The candidate will:

Perform integrative analyses of transcriptomic data to identify and validate novel therapeutic targets and pathways, prioritize indications, and decipher drug mechanisms of action and drug response/non-response mechanisms

Developing analytical pipelines along with data integration methodologies to enable mining of large complex datasets including multi-omics and clinical data.

Evaluate and develop new multi-omics and systems biology methods aligned with the group strategy and therapeutic projects needs

Collaborate with data engineering and data science teams within the computational biology cluster to develop informatics solutions with proper data governance and management guidelines to create harmonized datasets to enable rapid automation of analytical capabilities

As part of PMCB, form strong scientific partnerships, contribute and lead cross-functional programs in collaboration with the other PMCB clusters through integrating transcriptomic analysis with functional genomics assays, high throughput proteomics, single cell applications to drive added value for drug development programs

Partner with our therapeutic area teams to setup and lead innovative programs for therapeutic target identification and indication prioritization

Prepare publications, research and clinical/regulatory documentation in accordance with Sanofi quality standards. Author technical reports, study protocols and manuscripts for publication; present at internal and external meetings and conferences.


Ph.D. in Computer Science, Computational Biology, Bioinformatics, Data Science or a related discipline and at least 5 years of experience in industry or world-leading translational research academic

Proven track record of publishing relevant bioinformatics, computational biology and multiomics peer-reviewed journals.

Proficiency in transcriptomic data analysis including transcriptomic fingerprint similarity methods (CMap…), gene set enrichment, network inference (WGCNA…) and good knowledge of systems biology modeling (Bayesian/boolean network models…)

Experience with multi-omics integration projects including genetics, epigenetics, transcriptomics, proteomics, single cell, and functional genomic screens (CRISPR, perturseq…)

Demonstrated experience with Rmarkdown or Jupyter in a high-performance computing environment and cloud computing environment (AWS); working in a Linux environment.

Ability to work in a highly interactive environment with a diverse team of colleagues and external collaborators and to serve as team leader or team player in cross-functional teams

Outstanding communication skills and an ability to summarize and present the results of transcriptomic analysis, multi-omics integration and systems biology studies to a variety of audiences

Ability to work in a fast-paced, goal-oriented team environment, inspired by Sanofi play-to-win strategy

At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce - and workplace - which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.

According to the CDC, an individual is considered to be "fully vaccinated" fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE.




At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.
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