Associate Scientist I/II, Cell Biology - 2298

Job Description
What if you could repair broken genes? That is the question we ask ourselves at Editas Medicine. Were focused on translating the power and potential of the CRISPR/Cas9 and CRISPR/Cpf1 (also known as Cas12a) genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for many diseases. Were looking for talented, dedicated, passionate people to join our team and help us pioneer this field and do big, bold things that have never been achieved before. Are you full of hope, possibilities, and a belief that, working together, we can truly revolutionize the development of medicines to help patients around the world? If the answer is yes, then Editas Medicine is the place for you.

Editas Medicine is seeking a highly motivated in vitro cell biologist at the level of Associate Scientist I/II to join our Gene Editing Target Research group. In this role, you will support on-going efforts to develop gene editing therapies for ocular indications and for exploratory new targets in non-ocular tissues/organs. You will contribute to the development of cell-based assays and ex vivo methods to evaluate the extent and effects of gene editing. An ideal candidate should have a background in primary cell culture (e.g., primary hepatocytes, ocular cells, or stem cells), microscopy, and molecular biology, as well as a track record of creative thinking and a strong interest in genome editing. The successful candidate will be part of a dynamic, multidisciplinary discovery team dedicated to the development of gene editing-based therapies for major disease indications.

Key Responsibilities:

• Develop and optimize of primary cell-based assays
• Plan, perform, and analyze DNA/RNA extraction, qPCR and ddPCR
• Develop and optimize protein quantification assays such as Western blot and ELISA
• Perform microscopy, including high content imaging and analysis
• Analyze and present data within the organization
• Share responsibility in maintaining lab equipment and reagent inventory
• Maintain an electronic lab notebook and contribute to supporting documentation

Requirements

Minimum Requirements:

• BS and 5-7+ years or MS and 3-5+ years in cell biology or related field with 4+ years of laboratory experience in the biotechnology or pharmaceutical industry
• Experience with mammalian cell culture, including primary cells
• Proficient in molecular biology analyses such as qPCR and ddPCR
• Experience developing and validating immunoassays (immunofluorescence, Jess automated Western Blot and ELISA)
• Experience troubleshooting assays, including conducting scientific literature searches and reviews
• Results-driven with excellent attention to details and ability to independently execute protocols
• Excellent written and oral communication skills
• Ability to work in a team-oriented, multidisciplinary environment

Preferred Qualifications:

• Experience with formulating and working with lipid nanoparticles
• Experience working with AAV and lentiviral vectors
• Experience with dissection and microdissection, isolation of DNA/RNA from tissue