Veterans Preferred - Research Scientist, Computational Biology

Military Veterans are Encouraged to Apply.

Kite is continuing to hire for all open roles. Our interview process may be conducted virtually and some roles will be asked to temporarily work from home. Over the coming weeks and months, we will be implementing a phased approach to bringing employees back to site to ensure the health and safety of our teams.

For Current Kite Pharma Employees and Contractors:

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Job Description

Research Scientist, Computational Biology

Product Attributes Sciences, Analytical Ops, Process Development

Job Overview

The Research Scientist will be responsible for dissecting and analyzing large amounts of datasets generated at the molecular level, e.g. genomics, transcriptomics, and proteomics, in order to gain insight into the biology of cell therapy products. They will work in a cross-functional team to enhance in-process attribute and product understanding to identify biomarkers predictive of manufacturability. In this role, the ideal candidate will create or select mathematical models, develop simulations, and perform pattern analysis of biological systems to identify opportunities for continuous process improvement.

We are seeking a highly motivated and passionate Computational Biologist build analytical models to observe trends, discover patterns, and use that information to predict process performance and product manufacturability. The successful candidate will utilize bioinformatic tools to enhance understanding of key pathways that drive T cell response, proliferation, and differentiation within product manufacturing along with elucidating the mechanism of action of final product. The candidate will also be responsible for establishing and documenting the workflow for bioinformatic platforms from analysis through data visualization. The successful candidate will represent Analytical Development in multiple cross-functional teams projects and opportunity to learn about process development and enable next generation of cell therapy development using computational biology approaches.

Job Responsibilities and Duties

• Building capabilities to analyze large biological data sets to enhance in-process attribute and product understanding
• Develop bioinformatic workflows for data analysis, visualization, and predictive analytics for data generated from flow cytometry as well as data generated from molecular biology platforms
• Perform assessment of new bioinformatic and business intelligence tools to drive continuous process improvements
• Lead cross-functional efforts to compile specialized reports and data visualizations using standard business reporting and scientific data analysis applications
• Author, review, and edit technical documents, i.e. SOPs and/or reports, describing data analytics workflow

Basic Qualifications:

• Ph.D. in Computational Biology or related discipline with 0 + years of experience or M.S. with 6+ industry experience or Bachelors Degree with 8+ years of industry experience

Preferred Qualifications:

• Advanced knowledge of cell biology, cancer biology, and/or immunology preferred

• Experience with designing and developing data models and databases (SQL, mongoDB)
• Experience with visualization tools (Tableau, Spotfire, RShiny)
• Experience with analyzing nex-generation sequencing, microarray, qPCR datasets; knowledge of scRNAseq, CITEseq, TCRseq desired
• Experience with statistical software systems like JMP, SPSS and SAS
• Fluent in programming languages, e.g., R, Python, or any relevant modern programming languages
• Solid understanding of biostatistics and AI/ML algorithms and associated applications
• Familiar with cloud environments (AWS, s3 buckets) and knowledge of data science infrastructure (data-bricks, H2O.ai)
• Understanding of GxP and GMP is a plus
• Experience with LabKey, data management system, is a plus
• Experience with lab instrument automation is a plus
• Experience with building IT infrastructure is a plus
• Effective verbal and written communication skills
• Ability to think critically and demonstrate troubleshooting and problem-solving skills
• Ability to work in a fast-paced small company environment with minimal direction

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Kite is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid, long-term durable response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune system's ability to recognize and kill tumors. Kite is based in Santa Monica, CA. For more information on Kite, please visit www.kitepharma.com . Sign up to follow @KitePharma on Twitter at www.twitter.com/kitepharma .

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As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability,genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@gilead.com for assistance.

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For Current Kite Pharma Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.