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Scientist, T Cell Biology

Precigen, Inc
Germantown, Maryland, US
Closing date
Oct 10, 2022

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Academic / Research, Consultancy/Private Sector
Conservation science
Salary Type
Employment Type
Full time
Job Description
Precigen is seeking a highly motivated and creative Scientist (level determined by candidate experience) with experience in T cell biology, chimeric antigen receptor generation (CARs) and CAR T cell analysis to join Precigen's ImmunoOncology Department in Germantown, Maryland. ImmunoOncology is a rapidly growing and exciting area of cancer therapy, with the promise to revolutionize the way patients are treated. The successful candidate will have an in-depth understanding of T cell biology and immunotherapy.

Upon hire to this position Precigen will require documentation of a COVID-19 vaccination or exemption for medical or religious reasons.

  • Apply expertise in T cell immunology and molecular biology to lead and influence projects within the development of Precigen's product portfolio.
  • Plan the evaluation strategy and conduct the in vitro studies with human T cells for functional testing
  • Plan, perform and assess novel adoptive T cell therapies anti-tumor activity in relevant in vivo murine models.
  • Clear communication in both oral and written form.
  • Manage timelines and deliverables.
  • Develop reports for various projects.
  • Supervise research associates.
  • Utilization of appropriate technology, i.e. Outlook, PowerPoint, and other programs to create and distribute reports and key information.
  • Coordination of parallel tasks across multiple projects, demonstrating prioritization.
  • Interpret and effectively execute upon a variety of instructions provided in written, oral, diagram or schedule formats.
  • Self-motivated and independently minded.
  • Positive interpersonal skills with the ability to interact with individuals from a variety of levels and function.
  • Self-organizer, meticulous hands-on habits, keen attention to detail.
  • Strong quantitative and analytical skills.
  • Responsive, can-do attitude.

  • TBD

  • Ph.D. in immunology, cellular and/or tumor biology or a closely related field.
  • Strong background in cancer immunotherapy or the biology of the tumor microenvironment, human immunology and experience working with engineered T-cells strongly preferred.
  • Five (5) or more year's post-doctoral experience, industry experience a plus.
  • Direct hands on experience with generating and analyzing chimeric antigen receptor (CAR) T cells function
  • Must have experience in flow cytometry and fluorescence activated cell sorting (FACS), immune cell phenotyping of immune cell subsets; experience with human immune cells is preferred
  • Experience designing and developing primary immune cell assays using key immune cell populations.
  • Hands-on expertise in T-cell functional characterization assays including in vitro cytotoxicity, proliferation, and cytokine/chemokine measurements.
  • Expertise in in vitro T-cell isolation and expansion methods.
  • Proficient in cell culture aseptic technique.
  • Experience in viral and non-viral methods of gene transfer.
  • Experience with PK/PD, in vitro T cell assays, including ELISPOT, ELISA, Luminex and flow cytometry read-out.
  • Proficient in multi-parameter flow cytometry (panel design, sample acquisition, data processing.)
  • Experience in molecular and cellular biology techniques, including but not limited to: PCR, qPCR, cloning and western blot.
  • Proficiency in the analysis and understanding of immune cells and molecules.

  • Ability to understand and execute on the company's mission and values.
  • Maintain a high degree of ethical standard and trustworthiness.
  • Capable of fostering change in an organization.
  • Deals with conflict in a direct, positive manner.
  • Ability to think and adapt to a rapidly changing environment and demands.
  • Able to reach rational conclusions through complex processing of information.
  • Fosters innovation through creative solutions.
  • Effective organization and implementation of group projects.
  • Maintain a high degree of accuracy and attention to detail.
  • Energized by accomplishments and excellence in the workplace.
  • Capable of high performance in independent work as well as in team setting.
  • Comfortable in a fast-paced small company environment with minimal direction and able to adjust workload based upon changing priorities.


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