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Molecular Biologist

Mason Grey Corporation
Spring House, Pennsylvania, US
Closing date
Oct 9, 2022

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Academic / Research, Consultancy/Private Sector
Conservation science
Salary Type
Employment Type
Full time
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Job Description
POSITION: Molecular Biologist Junior Level


LOCATION: Client Site, Spring House PA


This position in Gene Therapy and Gene Delivery Platforms group of Biotherapeutics offers an exciting opportunity to help develop novel Gene Therapies for unmet medical needs. We are investigating the use of Adeno-Associated Virus (AAV) vectors to deliver therapeutic proteins to patients for disease prevention as well as treatment of retinal, neuro, and infectious diseases.

We are seeking a highly motivated scientist to join a group that is engineering new AAV therapeutic vectors for lead indications and for evaluating advanced Gene Therapy technologies. These technologies include development of a scalable AAV manufacturing platform in human cells and improving AAV potency and tropism for relevant tissues and cell types.

The job requires a molecular biologist with experience cloning and purifying plasmids. Key characteristics include but are not limited to: ability to handle tight timelines and delivery of quality data; highly-organized and capable of handling multiple projects simultaneously; capable of carrying out established procedures and protocols with minimal direction.

Primary responsibilities:
Assist efforts to construct therapeutic plasmids and viral vectors using molecular cloning methods designed to maintain viral repeat regions
Purify plasmids by Qiagen anion-exchange chromatography columns
Perform restriction mapping and submit DNA sequencing samples to QC final plasmids
Organize and help maintain the plasmid inventory Maintain an electronic lab notebook (ELN) to document results
Contribute to a collaborative, creative, and rigorous culture of scientific discovery

Requirements Experience and Skills:

B.S. with at least 2 years or A.S. with 3-5 years of relevant post-graduate laboratory experience in the pharmaceutical industry or academic environment
Experience constructing plasmids using traditional restriction/ligation or isothermal assembly (In-Fusion/HiFi/Gibson) methods
Experience purifying plasmid DNA by Qiagen or similar anion exchange chromatography columns
Ability to follow established protocols with minimal guidance

Experience performing plasmid QC analyses, including diagnostic restriction digests and Sanger sequencing
A general understanding of virology and cell biology vectors
Cross-functional team experience in an industry environment
Experience with documentation and reporting of results using electronic lab notebooks is preferred

All candidates shall be legally authorized to work in the US and are subject to background screening, drug testing and verification of legal status in the United States using eVerify.
Company DescriptionThe Mason-Grey Corporation provides engineering solutions and services to process industry clients in energy, metals, plastics, biotech, pharmaceutical, and other key process markets. Today Mason-Grey executes projects and provides services to the Fortune 500 and mid-tier companies from coast to coast. Mason-Grey employees live and work in support of our mission from Massachusetts to California. Mason-Grey is headquartered in Atlanta, Georgia.
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