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Post-Doctoral Fellow - Biologist in Cancer Drug Discovery

SEngine Precision Medicine.
Seattle, Washington, US
Closing date
Oct 4, 2022

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Academic / Research
Informatics / GIS
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Job Description
Job Description: Post-Doctoral Fellow - Biologist in Cancer Drug Discovery

SEngine Precision Medicine is a Seattle based biotech company striving to fulfill the promise of personalized medicine by combining cancer diagnostics and drug discovery. Our CLIA certified high-throughput screening platform for patient derived organoids is not only guiding treatment decisions for individual patients, but also offers a unique opportunity to accelerate the discovery of novel cancer drugs. Our environment is rigorous, fast-paced and collaborative, bringing together passionate individuals who are making a positive impact in the lives of cancer patients. We inspire creativity and discovery by embracing an open culture that fosters innovation, teamwork and excellence .


The company is seeking a highly motivated Post-Doc Biologist in Cancer Drug Discovery to help advance, and build value in, SEngine's proprietary pre-clinical pipeline of cancer drugs. The candidate will have a strong background in mammalian cell culture - deep experience with monolayer culture required and experience with growing organoids from primary cancer and normal tissues is ideal. Experience with cancer research relevant cell biology, molecular biology, and biochemical techniques is also required. This position will directly contribute to progression of SEngine's internal drug discovery programs and will be ideal for a new PhD scientist looking to move from academia to industry - the position start date will be Q4 2022 to early Q1 2023. Successful research will provide opportunities to publish in peer-reviewed journals.

This position reports directly to the Director of Drug Discovery and will share responsibilities for managing drug discovery Research Associates.

  • Maintain human cell cultures of both monolayer cell lines and 3D patient-derived tumor organoids and normal tissue
  • Cell biology assays, such as Western blotting and microscopy, to characterize small molecule inhibitors on the cellular level
  • Molecular biology assays such as DNA, RNA, & protein isolation, from cell cultures
  • Apply functional genomics techniques (siRNA, shRNA and CRISPR) on cultured cells for drug target biology exploration
  • Flow cytometry/FACS experiments
  • Small molecule compound handling and management
  • Use of state-of-the-art liquid handling robotics/instruments to plate and treat cells with small molecules in multi-well plates
  • Perform combination drug treatments of cells to find synergistic drug combinations
  • Interact directly with drug discovery CROs and other partners to manage outsourced drug discovery work
  • Assist in the design of mouse model experiments to test and characterize small molecule inhibitors with partners/collaborators
  • Work with bioinformatics team to discover ideal patient populations and predictive biomarkers of response
  • Effectively communicate across teams and functional groups
  • Initiate and follow through on writing papers for peer-reviewed journal submissions
  • Maintain a detailed electronic laboratory notebook

  • PhD or MD/PhD in Oncology, Cell Biology, Drug Discovery, or relevant field
  • 0-3 years of experience after completion of doctorate - this will be a first or second post-doc, ideal for a scientist looking to explore a career in industry
  • Deep experience in mammalian cell culturing, ideally including culturing organoids derived from human tumor and/or normal tissue
  • Deep knowledge of principles of cell signaling pathways
  • Experience with general cell & molecular biology and biochemistry wet-lab techniques
  • Strong attention to detail and ability to execute on parallel and multi-faceted projects
  • Ability to set priorities across multiple projects and meet deadlines in a fast-paced environment
  • Professional working proficiency in Microsoft Office and GraphPad Prism
  • Outstanding written and oral communication skills
  • The following qualifications are a plus, but not required:
    • Familiarity with general principles of Medicinal Chemistry
    • Knowledge in the fields of cancer cell biology, pre-clinical small molecule (kinase and non-kinase) drug discovery, pre-clinical toxicology & PK, and bio-statistics
    • Experience managing interactions with external partners (collaborators, partners, CROs)
    • Knowledge in cancer genomics: cancer gene mutations and oncogene function
    • Experience working with protein degrading small molecules, such as PROTACs or Molecular Glues
    • Previous experience with normal/non-cancer cellular assays, such as hematological colony forming unit (CFU) assays, to assess potential toxicities of drugs

  • Ability to speak clearly so others can understand
  • Ability to see details at close range (within a few feet of the observer)
  • Ability to sit for lengthy periods of time
  • Ability to stand for lengthy periods of time in a lab environment
  • Ability to lift up to 15 lbs.
  • Ability to learn innovative technology (i.e., computer software, online programs, company systems, etc.) that enhance productivity and improve performance
  • Ability to develop specific goals and plans to prioritize, organize, and accomplish work

Job Type: Full-time, in person

Join us! SEngine Precision Medicine offers a competitive compensation and benefits package. Please apply with a short cover letter and resume. You are also welcome to call 206-788-5083 for questions.

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SEngine Precision Medicine is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, gender, religion, national origin, disability, and veteran status.

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