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Scientist I, Cancer Biology and Translational Sciences

Notch Therapeutics
Seattle, Washington, US
Closing date
Oct 10, 2022

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Academic / Research
Conservation science
Salary Type
Employment Type
Full time
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Job DescriptionSalary:

Role Summary:

The candidate will be part of a highly cross functional Cancer Biology and Translational Sciences group in Seattle. The Cancer Biology group works closely with multiple groups including Protein and Cell Engineering, Stem Cell and Developmental Immunology, Process Development and Computational Biology groups to develop in vitro models for assessing the function of engineered T-cells and understanding the clearance of allogeneic T-cell products. The candidate will actively perform experiments to further the understanding of biology of iPSC derived T-cells, evaluate novel strategies to mitigate allogeneic clearance of iPSC derived T-cells and advance early discovery efforts for identifying novel CAR candidates.

About Notch (
Notch is developing a pipeline of cellular immunotherapies originating from pluripotent stem cells that are specifically engineered to address the underlying biology of complex disease systems. The company has unlocked the ability for large-quantity production of T cells and other cells from any source of stem cells to bring best-in-class cell therapies for cancer and other immune disorders to thousands of patients. The core of the Notch platform is the Engineered Thymic Niche (ETN), which enables precision control of cell fate during the differentiation and expansion of stem cells in suspension bioreactors without the need for feeder cells or serum. The ETN has the potential to generate immunotherapies with decreased variability, increased potency, and engineered improvements. The technology was invented in the laboratories of Juan-Carlos Zúñiga-Pflücker, Ph.D. at Sunnybrook Research Institute and Peter Zandstra, Ph.D., FRSC at the University of Toronto. Notch was founded by these two institutions, in conjunction with MaRS Innovation (now Toronto Innovation Acceleration Partners) and the Centre for Commercialization of Regenerative Medicine (CCRM), which initially incubated the company.

  • Leverage T cell biology, tumor biology, tumor microenvironment expertise in collaborative efforts with scientists to investigate, develop and implement novel strategies for next-generation iPSC derived T-cell products
  • Lead, design, coordinate and execute proof-of-concept research with timely data analysis, interpretation, and communication to key stakeholders.
  • Hands on expertise in in vitro functional assays (including cytokine release/degranulation and Incucyte based short/long-term killing assays)
  • Expertise in processing and banking cells from Leukopaks.
  • Perform CRISPR based gene modification and generate cell lines and primary T cells.
  • Execute experiments to test novel approaches to assess allogeneic clearance of iPSC derived cells by T/NK cells.
  • Provide strategic input and scientific direction in the development of novel allogeneic cell therapies.
  • Work with colleagues to maintain laboratory in good working order as well as uphold standards of safety.
  • Maintain electronic laboratory notebooks and other documentation as need for regulatory filings.

Required Qualifications and Experience:
  • PhD with 2+ years or MS with 5+ years of experience.
  • Background in Cancer Biology, or Immunology.
  • Experience working with engineered T-cells (CAR/TCR).
  • Experience with execution and data analysis of multi-parameter flow cytometry, Incucyte killing assays and multiplexed cytokine release assays.
  • Critical thinking and an ability to read and analyze scientific publications in the field.
  • Experience handling multiple priorities with a focus on alignment with company goals.
  • Experience with Electronic Laboratory Notebooks (ELN)
  • Practical experience with gene-editing and/or gene-engineering concepts is preferred, but not required
  • Willingness to think outside the box, be creative and ability to work in a very fast paced, ever changing environment.

Employment with Notch is conditional upon providing documentation to confirm receipt of both doses of an approved Covid-19 vaccine. Notch will consider exemptions to this requirement based on legitimate medical or religious grounds.

Notch Therapeutics Inc. is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by feder al, provincial or local law.

Requests for accommodation can be made at any stage of the recruitment process providing the applicant has met the Bona-fide requirements for the open position. Applicants need to make their requirements known when contacted.
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