(Sr.) Principal Scientist, Computational Biology - 108

(Sr.) Principal Scientist, Computational Biology - 108
Axcella is a clinical-stage biotechnology company pioneering the research and development of novel multi-targeted interventions to treat complex diseases and improve health. Our product candidates are generated from our proprietary, human‑focused development platform and harness the power of endogenous metabolic modulators (EMMs), a broad family of molecules that fundamentally impact and regulate human metabolism.

We are growing quickly as we advance in the clinic, and we are seeking exceptional people to join our team. We value bright minds, collaborative spirits and a willingness to think outside the box.

Position Summary

This Senior/Principal scientist role will be a key contributor to research activities and to some projects related to ongoing clinical trials. While working within a small team of Ph.D.-level computational scientists, the individual will also interface with biologists and sometimes clinicians. Projects will be fast paced and require both experience in statistical analysis and skill at finding innovative solutions.

Duties and Responsibilities

·Ingestion of diverse omics data types (RNAseq, Proteomics and Metabolomics) and assays

·Statistical analyses of small and large datasets

·Implementation of predictive models (logistic regressions, random forests…) and cross validation of models

·Analyses combining omics data and prior knowledge (databases of functional categories, protein networks…)

·Reports via markdown pages

·Presentation of analysis results

·Contribution to infrastructure-related programming (import of databases and R-shiny apps)

·Experimental design in collaboration with biologists

· Required competencies :

· 8+ years of programming

· Fluent in at least one of R, Python, C or Java

· Algorithms (some knowledge of CLRS)

· Statistics and good foundation in probability theory

· Experience with classification, regression and cross-validation techniques

· Ability to work in a small team of computational scientists with strong emphasis on collaboration

· Desire to collaborate with and learn from biologists

· Take ownership of data analysis projects

· AWS, cloud computing

· Knowledge of biology

Education and Experience

·At least 5 five years of work experience. Industry preferred. Experience in Biotech/Tech a plus.

·Ph.D. in Statistics, Computational Biology, Bioinformatics, Mathematics, Computer Sciences or Physics

·MS/BS in Statistics, Mathematics, Electrical Engineering or Computer Sciences

Joining Axcella Therapeutics offers the potential to be part of a groundbreaking organization. We are growing quickly as we advance in the clinic, and we are seeking exceptional people to join our team. We value bright minds, collaborative spirits and a willingness to think outside the box.

EEO Statement: Axcella Therapeutics is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status.

Recruitment & Staffing Agencies: Axcella Therapeutics does not accept unsolicited agency resumes. Agency resumes will only be accepted if the agency is formally engaged by Axcella Therapeutics Human Resources.

*Axcella Therapeutics conducts Non-Investigational New Drug (IND"), Institutional Review Board-approved Clinical studies to evaluate the safety and tolerability of our AXA candidates in human subjects, or effects on the normal structure or function of the body. Studies intended at the time of initiation to support drug development will be conducted under an IND.