Senior Scientist / Principal Scientist, Computational Biology and Bioinformatics
- Employer
- Northwestern University
- Location
- Chicago, Illinois, US
- Salary
- Competitive
- Closing date
- Sep 25, 2022
View more
- Sector
- Academic / Research
- Field
- Informatics / GIS
- Discipline
- Modeling, Biology
- Salary Type
- Salary
- Employment Type
- Full time
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- Senior Scientist / Principal Scientist, Computational Biology and Bioinformatics
Jounce Therapeutics
Cambridge, Massachusetts, United States (on-site)
We are seeking an experienced Computational Biologist/Bioinformatician to contribute to the Translational Genomics team at Jounce. We are looking for someone with superior technical skills who can help us use data-driven approaches to advance our programs and inform biomarker strategy. This person will lead the biomarker strategy efforts on an early stage clinical development program as well as contribute to preclinical discovery efforts. Responsibilities include implementation and maintenance of next generation sequencing (NGS) pipelines and working with teams to design experiments to interrogate immune oncology pathways. The person in this position will work closely with both bioinformatics analysts and wet lab scientists to increase team capabilities and efficiency. The ideal candidate will also act as a partner with the Research Informatics team to help build new tools and build out cloud-based bioinformatics high performance computing capabilities. Experience with clinical biomarkers is a plus.
Responsibilities:
- Lead program-specific translational genomics strategy and participate in research team meetings, proactively suggest new ways to impact programs from discovery through the clinic;
- Develop novel algorithms and implement, validate, and maintain shared pipelines for processing of NGS data (targeted/whole exome, RNA, single cell, TCR, and/or BCR sequencing) and downstream analyses (e.g. TMB, HLA typing, MSI status determination, differential transcript expression);
- Evaluate and implement pipeline algorithms based on statistical quality and performance metrics on real and simulated data sets in order to keep our portfolio of tools cutting edge;
- Manage existing high-dimensional data resources and ingest new public and internal data sets for use by team members; and
- Use best practices for reproducible research and data stewardship.
Requirements
- A Ph.D. in Computational Biology, Bioinformatics, Computer Science, or a related field with 3+ years or a M.S. with 13+ years of relevant experience;
- Demonstrated problem-solving and data analytical skills;
- Highly organized and motivated individual, able to work well in a group setting as well as independently in a fast-paced environment;
- Excellent communication skills and the ability to prioritize and deliver research in a fast-paced, milestone-driven environment;
- Experience with public cancer biology databases and an understanding of how to utilize big data to drive discovery and development efforts;
- Deep understanding of next generation sequencing (NGS) methods and how upstream sample preparation and processing may affect sequencing results and their interpretation;
- Strong hands-on programming skills (R/Bioconductor, Python, SQL, Bash scripting or similar);
- Proficiency in LINUX system administration, shell scripting, software compilation, and version control systems;
- Familiarity with Amazon Web Services (AWS) or similar cloud-computing services; and
- Experience with machine learning, statistical modeling, and/or pathway/network analysis is beneficial.
Job Information
- Job ID: 64145754
- Workplace Type: On-Site
- Location:
Cambridge, Massachusetts, United States - Position Title:Senior Scientist / Principal Scientist, Computational Biology and Bioinformatics
- Company Name For Job:Jounce Therapeutics
- Job Function:Bioinformatics
- Job Type:Full-Time
- Job Duration:Indefinite
- Min Education:Master's Degree
- Required Travel:0-10%
Jounce Therapeutics, Inc. is a clinical-stage immunotherapy company dedicated to transforming the treatment of cancer by developing therapies that enable the immune system to attack tumors and aiming to provide long-lasting benefits to patients through a biomarker-driven approach. Jounce currently has multiple development stage programs ongoing while simultaneously advancing additional early-stage assets from its robust discovery engine based on its Translational Science Platform. Jounce's highest priority program, JTX-8064,...
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