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Senior Clinical Research Coordinator-Immunobiology Center

Mount Sinai Medical Center
New York City, New York, US
Closing date
Sep 27, 2022

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Academic / Research
Conservation science
Statistics, Biology
Salary Type
Employment Type
Full time
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Strength Through Diversity

Ground breaking science. Advancing medicine. Healing made personal.

The lab of Dr. Sacha Gnjatic is seeking a senior clinical research coordinator to manage studies in inflammatory bowel disease and immune-related colitis following checkpoint inhibitor therapy. You will work on two research studies led by our lab.

Project Description:

Project 1: Characterizing and predicting colitis in immune checkpoint blockade-treated patients with cancer

Since the first approval of ipilimumab, a monoclonal antibody targeting immune checkpoint CTLA-4, for

advanced melanoma in 2011, the landscape of cancer immunotherapy has blossomed with sustained

remissions for formerly incurable cancers. However, safety concerns have limited the broader implementation of this treatment, due to the occurrence of serious immune-related adverse events (irAEs). In particular, ipilimumab-induced colitis (irColitis) is the most common occurrence, with 10- 15% of patients developing it when administered alone or in combination with nivolumab. There is therefore an urgent need to comprehensively study the nature of irColitis and find whether potential risk factors could be identified and mitigated for greater safety and efficacy of combination treatments.

Project 2: Investigation of anti-GM-CSF autoantibodies as a disease determinant in Crohn's disease

We aim to determine if anti-granulocyte/macrophage-colony stimulating factor autoantibodies (GM-CSF AuAB) serve as consequential biomarkers to predict Crohn's disease (CD) onset, anticipate a complicated disease course, and inform disease pathogenesis. Previous studies have suggested that GM-CSF AuAB at diagnosis in children are associated with ileal or ileo-colonic disease and predict disease progression towards complications. More recently, members of our group have demonstrated that GM-CSF AuAB develop years prior to CD diagnosis with antibody titers increasing closer to time when symptoms are apparent and are also associated with complicated behavior at disease onset.

Roles & Responsibilities:
  • Manage specimen tracking systems
  • Recruit patients for observational clinical research study
  • Oversee the longitudinal collection of patient biospecimens
  • Be on-site for biospecimen collections
  • Develop project status reports including progress reports, consort diagrams, and grant reports
  • Present relevant project data, statistics, and analyses as appropriate
  • Record meeting minutes and action items during bi-monthly meetings
  • Host project management meetings with collaborating sites

  • Tech-Friendly: Open to working with multiple technology platforms
  • Working knowledge of R for data management, cleaning, and processing.
  • Interest in face-to-face interactions with patient populations, specifically patients with cancer
  • Able to communicate research goals to individuals with varying levels of scientific literacy
  • Strong presentation skills, including the development of visualizations for effective communication of data and presenting descriptive statistics
  • Experienced with conducting literature review
  • Suggested Qualifications:
    • Familiar with the CONSORT and STROBE
    • Familiar with observational study designs
    • Interest in developing project management plans in collaboration with senior team members
    • C1/C2 for Spanish, Russian, or Chinese
    • Familiar with citation management software
  • Education: Bachelor's degree in sciences or related field. Master's degree preferred
  • Experience: 5 years of clinical research
  • Excellent written and oral communication skills
  • Exceptional attention to detail and accuracy
  • Ability to manage multiple tasks & priorities
  • Knowledge of variety of concepts, practices and procedures in directly related field
  • Demonstrated leadership potential

Strength Through Diversity

The Mount Sinai Health System believes that diversity, equity and inclusion are drivers for excellence. We share a common devotion to delivering exceptional patient care. Yet we're as diverse as the city we call home- culturally, ethically, in outlook and lifestyle. When you join us, you become a part of Mount Sinai's unrivaled record of achievement, education, and advancement as we revolutionize medicine together and participate actively as a leader within the Mount Sinai Health System by:
  • Serving as the primary resource management representative of the Mount Sinai leadership teams, committees, etc., and acting as the primary executive leader interface between Mount Sinai and key executives from the health systems' vendors and partners.
  • Engaging with relevant thought leaders and policy-makers at the federal and state levels, and representing the Health System as assigned.
  • Using a lens of equity in establishing and promoting policies and procedures and providing opportunities for all to thrive.
  • Confronting racist, sexist or other inappropriate behavior and challenges exclusionary organizational practices and serving as a role model to promote anti-racist behaviors.
  • Inspiring and fostering an environment of anti-racist behaviors among and between departments and co-workers.

We work hard to acquire and retain the best people, and to create a welcoming, nurturing work environment where you can develop professionally. We share the belief that all employees, regardless of job title or expertise, can make an impact on quality patient care.

Explore more about this opportunity and how you can help us write a new chapter in our story!

Who We Are

Over 42,000 employees strong, the mission of the Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve.

Formed in September 2013, The Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with seven premier hospital campuses, including Mount Sinai Beth Israel, Mount Sinai Beth Israel Brooklyn, The Mount Sinai Hospital, Mount Sinai Queens, Mount Sinai West (formerly Mount Sinai Roosevelt), Mount Sinai Morningside (formerly Mount Sinai St. Luke's), and New York Eye and Ear Infirmary of Mount Sinai.

The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression.

EOE Minorities/Women/Disabled/Veterans
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