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Senior Scientist Computational Biology

North Cambridge, Massachusetts, US
Closing date
Aug 19, 2022

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Academic / Research
Informatics / GIS
Salary Type
Employment Type
Full time
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Sanofi Large Molecule Research Platform is opening a new senior scientist role to seek a computational biologist with strong expertise in computational biology, bioinformatics, artificial intelligence (AI), machine learning (ML), and deep learning (DL). The successful candidate will work in an interdisciplinary team to apply cutting-edge computation, AI/ML/DL, and structural biology technologies to resolve challenges in real-world drug discovery and make impacts to patients' life. This is an exciting opportunity to contribute to the process of design and engineering revolutionary biologics, including multivalent, multi-targeting molecules by leveraging proprietary data coming from our industry-leading high-throughput automation platforms. The successful candidate will gain deeper insight into drug development process and transform AI/ML algorithms into accelerating biologics discovery and development process.

  • Evaluate and develop state-of-the-art computational methods to decode biophysical and geometrical features, including structure and dynamics, from antibody-antigen datasets and create predictive models for engineering.
  • Develop and apply complex machine/deep learning solutions to our high-content and high-quality proprietary datasets, as well as public datasets.
  • Perform data querying and feature extraction to improve current workflow for antibody/nanobody engineering, including affinity modification, cross-reactivity engineering, liability risk prediction and mitigation, multi-specific antibody engineering, and de novo antibody design.
  • Maintain a keen awareness of recent developments in data science, bioinformatics, and state-of-the-art of AI/ML/DL algorithms, aiming to accelerate development of new computational algorithms.
  • Effectively collaborate with colleagues with diverse scientific background, identify problems and opportunities, combine computational and structural analysis to support large molecule projects.

  • Ph.D. with a minimum of 3 years' experience in computational structural biology, bioinformatics, computational chemistry, or computational physics or a MS degree with a minimum of 5 years' experience
  • Significant experience in data science and machine learning.
  • Understanding of protein structure and protein-protein interaction. Hands-on experience with structural analysis and optimization of biochemical and biophysical properties, like thermodynamics, with protein design tools e.g. Rosetta, BioLuminate, or MOE, etc.
  • Strong familiarity with core concepts in Deep Learning and Neural Networks including CNNs, RNNs, Embeddings, Transfer Learning, Attention-based Networks, Statistical Learning.
  • Familiarity with deep learning libraries such as Keras, TensorFlow, PyTorch, and bioinformatics pipelines
  • Experience of developing computational prediction models for protein engineering through programming with Python, Shell, or SVL, etc. Experience with cloud computing, parallel computing, and/or supercomputing is expected.
  • Familiarity with Data Visualization tools/libraries and dimensionality reduction algorithms.

  • Familiarity with protein structure or sequence featurization and learned embeddings. Experience with database mining, big data, and large-scale virtual screening using Bayesian optimization etc.
  • Understanding of biologics R&D process is a plus.

At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce - and workplace - which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.

According to the CDC, an individual is considered to be "fully vaccinated" fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE.



At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

This employer is a corporate member of myGwork - LGBTQ+ professionals, the business community for LGBTQ+ professionals, students, inclusive employers & anyone who believes in workplace equality.
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