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Senior Associate Scientist, Biology/Immuno-Oncology

Employer
Mersana Therapeutics
Location
Cambridge, Massachusetts, US
Salary
Competitive
Closing date
Aug 16, 2022

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Sector
Academic / Research
Field
Conservation science
Discipline
Biology
Salary Type
Salary
Employment Type
Full time
Senior Associate Scientist, Biology/Immuno-Oncology

Mersana Therapeutics is a clinical-stage biopharmaceutical company using its differentiated and proprietary ADC platforms to rapidly develop novel ADCs with optimal efficacy, safety and tolerability to meaningfully improve the lives of people fighting cancer. Mersana's lead product candidate, upifitamab rilsodotin (UpRi), is a Dolaflexin ADC targeting NaPi2b and is being studied in UPLIFT, a single-arm registrational trial in patients with platinum-resistant ovarian cancer, as well as in UPGRADE, a Phase 1/2 umbrella trial evaluating UpRi in combination with other ovarian cancer therapies. Mersana's earlier stage programs include XMT-1660, a Dolasynthen ADC targeting B7-H4, and XMT-2056, a STING-agonist ADC developed using the company's Immunosynthen platform and targeting a novel epitope of human epidermal growth factor receptor 2 (HER2). In addition, multiple partners are using Mersana's platforms to advance their ADC pipelines. Mersana Therapeutics was recently named among the 2021 Top Places to Work in Massachusetts by The Boston Globe. Mersana routinely posts information that may be useful to investors on the "Investors and Media" section of its website atwww.mersana.com.


Job Duties:


Conduct laboratory research and contribute both to discovery pipeline programs and mechanistic studies with Mersana's proprietary Immunosynthen platform. Work on antibody-drug conjugate (ADC) platforms to develop highly targeted drugs with increased tolerability and expanded opportunities to deliver meaningful clinical benefit to patients. Job duties include the following: Design and execution of experiments, data analysis and interpretation, clear communication of the results and proper record keeping. Generate experimental data that directly informs key decisions for project teams; participate in the decision-making by sharing expertise and perspective; develop technical skills by mastering new techniques, learning from colleagues in chemistry, bioconjugation, and pharmacology; serve as "go-to" subject matter expert in the assays used to evaluate immune-stimulating ADCs, including complex cancer cell and immune cell co-culture assays.

Requirements:

Must have MS in immunology, cell biology, biology, or closely related scientific field and 5 years of industry research experience in drug development, including experience with primary immune cell isolation/culture/assays, multicolor flow cytometry, phenotyping, ELISA, Western blots, and assay development/trouble shooting. We will also accept a BS and 7 years of industry research experience in stated areas.

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